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US 12,729,381 B2Granted
Methods and compositions for inactivating interleukin-2-inducible t-cell kinase (ITK)
AssigneeThe Research Foundation for The State University of New York
InventorsMobin Karimi, Alaji Bah
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Abstract
The present disclosure relates to compositions and methods for administering a subject in need thereof an effective amount of an inhibitor of interleukin-2-inducible T-cell kinase (ITK). In embodiments, the polypeptide of the present disclosure is characterized as an inhibitor and includes an amino acid sequence having at least 80% sequence identity to SEQ ID NO: 2, wherein the peptide inhibitor includes a phosphorylated tyrosine.
Claims4
A synthetic nucleic acid encoding a peptide inhibitor having a sequence identity to SEQ ID NO:
- 2, wherein the peptide inhibitor comprises a phosphorylated tyrosine.
Dependencies are inferred from the claim text.