Immunotherapy method of targeted chemokine and cytokine delivery by mesenchymal stem cell
AssigneeChangen Therapeutics (Shanghai) Co., Ltd.
InventorsWei Qiang Gao, Bin Ma, Pan Yin
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Abstract
An immunotherapy method of targeted chemokine and cytokine delivery by a mesenchymal stem cell that expresses an immunostimulatory factor. The immunostimulatory factor is selected from the following group: CCL3, CCL19, CCL21, XCL1, CXCL9, OX40L, 4-1BBL, GITRL, CD40L, or a combination thereof. At a tumor site, the mesenchymal stem cell specifically attracts and activates an immune cell that kills tumor tissue, and the mesenchymal stem cell has a synergistic effect with chemokines and/or cytokines, having an immunotherapeutic effect with higher efficiency and few side effects, and a significantly enhanced ability to kill tumor tissue, especially colorectal cancer cells.
Claims10
A mesenchymal stem cell expressing the following immunostimulatory factors:
- (1) CXCL9 and GITRL;
- (2) CXCL9, 4-1BBL and GITRL;
- or
- (3) CXCL9, GITRL and CD40L.
Dependencies are inferred from the claim text.