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US 12,729,371 B2Granted
Compositions and methods for haematopoietic stem cell transplantation
AssigneesOspedale San Raffaele S.R.L., Fondazione Telethon
InventorsClaire Latroche, Luigi Naldini, Maura Manzi
Life of this patent
Estimating the term…
Abstract
Use of CD47 and/or C-X-C chemokine receptor type 4 (CXCR4) for increasing engraftment by haematopoietic stem and/or progenitor cells (HSPCs).
Claims8
A population of genetically engineered haematopoietic stem and/or progenitor cells (HSPCs), wherein the HSPCs are genetically engineered to transiently express CD47 and/or C-X-C chemokine receptor type 4 (CXCR4), wherein the CXCR4 is encoded by a sequence having at least 90% sequence identity to the sequence set forth in SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.