T cell receptors specific for a mutant form of the RET oncogene and uses thereof

An isolated T cell receptor (TCR) having antigenic specificity for a mutant form of the rearranged during transfection (RET) proto-oncogene with a methionine to threonine substitution at position 918 of SEQ ID NO:

• 11, wherein the TCR comprises:
• (a) an alpha chain variable region comprising a complementarity determining region 1 (CDR1), a CDR2 and a CDR3;
• and
• (b) a beta chain variable region comprising a CDR1, a CDR2 and a CDR3,
• wherein:
• the alpha chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 46-51, 69.75 and 110-120 of SEO ID NO:
• 2, and the beta chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 46-50, 68-72 and 111-119 of SEQ ID NO:
• 4;
• the alpha chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 47-53, 71-78 and 113-123 of SEQ ID NO:
• 6, and the beta chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 46-49, 67-72 and 111-123 of SEO ID NO:
• 8;
• or
• the alpha chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 53-58, 76-82 and 117-129 of SEQ ID NO:
• 19, and the beta chain variable region CDR1, CDR2 and CDR3 respectively comprise residues 46-50, 68-73 and 112-126 of SEO ID NO:
• 21.