Optical measurement of biological tissue
AssigneeOptics11 B.V.
InventorsKevin Bielawski, Niek Rijnveld, Grzegorz Gruca, Ramkumar Raghuraman, Jakob Pyszkowski, Matthias Haalstra, Kyle Juedes
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Abstract
An optical measurement assembly includes a tissue suspension device having two cantilevers between which a biological tissue can be suspended. This assembly further an optical waveguide having an end that faces a surface part of one of the two cantilevers. The surface part is optically reflective so that the optical waveguide and the surface part form an interferometric cavity. This interferometric cavity has a spectral response that varies as a function of a degree of flexion of the cantilever of which the surface part faces the optical waveguide.
Claims19
An optical measurement assembly comprising:
- a tissue suspension device having two cantilevers between which a biological tissue can be suspended;
- and
- an optical waveguide having an end that faces a surface part of one of the two cantilevers, the surface part being optically reflective so that the optical waveguide and the surface part form an interferometric cavity having a spectral response that varies as a function of a degree of flexion of the cantilever of which the surface part faces the optical waveguide.
A method of optically measuring at least one functional property of a biological tissue, the method comprising:
- providing a biological tissue that is suspended between two cantilevers of a tissue suspension device;
- positioning the tissue suspension device with respect to an end of an optical waveguide so that the end of the optical waveguide faces a surface part of one of the two cantilevers, the surface part being optically reflective so that the end of the optical waveguide and the surface part form an interferometric cavity having a spectral response that varies as a function of a degree of flexion of the cantilever of which the surface part faces the optical waveguide;
- measuring a change in the spectral response of the interferometric cavity;
- and
- calculating a force exerted by the biological tissue from the change in the spectral response of the interferometric cavity, the force being representative of a functional property of the biological tissue.
Dependencies are inferred from the claim text.