Back to results
US 12,729,241 B2Granted
Antibodies that bind to human chemokine (C-C motif) receptor 8 (CCR8)
AssigneeGilead Sciences, Inc.
InventorsLara Lewis Mcgrath, Fabien Dépis, Changyun Hu, Leonard G. Presta, Joshua Adam Buggé
Life of this patent
Estimating the term…
Abstract
Provided herein are various embodiments relating to antibodies and fusion proteins and uses thereof. Some of the embodiments include antibodies that bind CCR8. Some of the embodiments include fusion proteins that bind CCR8. Such antibodies and fusion proteins can be used in methods to treat, for example, cancer.
Claims30
An isolated antibody that binds human CCR8, wherein the antibody comprises:
- a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 84, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 85, a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 86, a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 87, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 88, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 89;
- wherein the antibody comprises a heavy chain comprising an amino acid sequence having at least 98% sequence identity to SEQ ID NO:
- 94.
6 more elements
An isolated antibody that binds human CCR8, wherein the antibody comprises:
- a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 100, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 85, a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 86, a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 87, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 88, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 89;
- wherein the antibody comprises a heavy chain comprising an amino acid sequence having at least 98% sequence identity to SEQ ID NO:
- 98.
6 more elements
An isolated antibody that binds human CCR8, wherein the antibody comprises:
- a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 84, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 85, a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 86, a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 87, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 88, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 89;
- wherein the antibody comprises a heavy chain comprising an amino acid sequence having at least 98% sequence identity to SEQ ID NO:
- 94, and a light chain comprising an amino acid sequence of SEQ ID NO:
- 95.
7 more elements
An isolated antibody that binds human CCR8, wherein the antibody comprises:
- a heavy chain complementarity determining region 1 (HCDR1) comprising the amino acid sequence of SEQ ID NO:
- 100, a heavy chain complementarity determining region 2 (HCDR2) comprising the amino acid sequence of SEQ ID NO:
- 85, a heavy chain complementarity determining region 3 (HCDR3) comprising the amino acid sequence of SEQ ID NO:
- 86, a light chain complementarity determining region 1 (LCDR1) comprising the amino acid sequence of SEQ ID NO:
- 87, a light chain complementarity determining region 2 (LCDR2) comprising the amino acid sequence of SEQ ID NO:
- 88, and a light chain complementarity determining region 3 (LCDR3) comprising the amino acid sequence of SEQ ID NO:
- 89;
- wherein the antibody comprises a heavy chain comprising an amino acid sequence having at least 98% sequence identity to SEQ ID NO:
- 98, and a light chain comprising an amino acid sequence of SEQ ID NO:
- 99.
7 more elements
Dependencies are inferred from the claim text.