Anti-CEACAM5 antibodies and conjugates and uses thereof

An immunoconjugate comprising an antibody covalently linked via a linker to exatecan, the immunoconjugate having a formula (IV):

• wherein:
• the antibody binds to human CEACAM5 protein and comprises:
• a CDR1-H consisting of the amino acid sequence of SEQ ID NO:
• 3,
• a CDR2-H consisting of the amino acid sequence of SEQ ID NO:
• 4,
• a CDR3-H consisting of the amino acid sequence of SEQ ID NO:
• 5,
• a CDR1-L consisting of the amino acid sequence of SEQ ID NO:
• 6,
• a CDR2-L consisting of the amino acid sequence of SEQ ID NO:
• 7, and
• a CDR3-L consisting of the amino acid sequence of SEQ ID NO:
• 8;
• S is a sulfur atom of the antibody, and
• n is between 1 and 10.