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US 12,729,226 B2Granted
KLF induced cardiomyogenesis
AssigneesVictor Chang Cardiac Research Institute, National Cerebral and Cardiovascular Center
InventorsKazu Kikuchi, III, Masahito Ogawa
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Abstract
The technology relates to a method for inducing cardiomyogenesis comprising administering a therapeutically effective amount of either or both of KLF1 and KLF2b to increase the level of KLF1 and/or KLF2b in the cardiomyocytes thereby inducing cardiomyogenesis.
Claims18
A method for inducing cardiomyogenesis comprising administering a therapeutically effective amount of a Krüppel-like transcription factor 1 (KLF1) to a cardiomyocyte, or inducing expression of the KLF1 in the cardiomyocyte, and wherein:
- (i.) the KLF1 protein has KLF activity;
- and
- (ii.) the KLF1 protein comprises the amino acid sequence of SEQ ID NO:
- 1, 11, or 12.
1 more element
Dependencies are inferred from the claim text.