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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsSamira Kiani, Tahere Mokhtari
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A non-naturally occurring zinc finger protein, wherein the zinc finger protein specifically binds to the promoter region of the Myd88 gene, is provided, as well as related polynucleotides, vectors, cells, and pharmaceutical compositions. In some aspects, the zinc finger protein comprises one or more repressors. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier and: (A) one or more RNA interference (RNAi) agents targeting the Myd88 gene, or related polynucleotides, vectors, or cells; (B) a target antigen or a polynucleotide encoding the target antigen; and (C) a gene therapy are also provided. Methods for ameliorating inflammation and/or immune response in a subject using the RNAi agents, zinc finger protein, polynucleotides, vectors, cells, and pharmaceutical compositions also are provided.
A non-naturally occurring zinc finger protein, wherein the zinc finger protein specifically binds to the promoter region of the Myd88 gene.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and:
A set of compositions comprising:
A method for inducing immune tolerance in a subject, the method comprising administering to the subject a therapeutically or prophylactically effective amount of:
Dependencies are inferred from the claim text.