Compounds for the treatment of human immunodeficiency virus
AssigneesThe Trustees of the University of Pennsylvania, Dana-Farber Cancer Institute, Inc.
InventorsAmos B. Smith, III, Althea Erica Gaffney, Joseph G. Sodroski
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Abstract
The present disclosure provides compounds of Formula (I) or pharmaceutically acceptable salts thereof: (I) wherein, R1 to R6 and X are defined herein. Also provided are pharmaceutical compositions comprising these compounds, methods for treating Human Immunodeficiency Virus (HIV-1) in a subject in need thereof using these compounds or pharmaceutical compositions, and methods for stabilizing the state-1 conformation of the HIV-1 envelope glycoproteins using these compounds or pharmaceutical compositions.
Claims26
A compound of Formula (I):
- wherein:
- (i) R1 to R5 are halo, or (ii) R1 to R5 are H or optionally substituted diazirinyl, provided that one of R1 to R5 is optionally substituted diazirinyl, or (iii) four of R1 to R5 are halo and one of R1 to R5 is N3;
- R6 is H, C1-6alkyl, or C1-6alkoxy;
- and
- X is absent, -furanyl-, or furanyl-C1-6alk-;
- or a pharmaceutically acceptable salt thereof.
A compound of Formula (I):
- wherein:
- R1 to R5 are, independently, H, halo, optionally substituted C1-6alkyl, optionally substituted diazirinyl, or N3;
- R6 is C1-6alkoxy;
- and
- X is absent,-furanyl-, or furanyl-C1-6alk-;
- or a pharmaceutically acceptable salt thereof.
A compound of Formula (I):
- wherein:
- R1 to R5 are, independently, H, halo, optionally substituted C1-6alkyl, optionally substituted diazirinyl, or N3;
- R6 is C1-6alkyl;
- and
- X is absent, -furanyl-, or furanyl-C1-6alk-;
- or a pharmaceutically acceptable salt thereof.
A compound of Formula (I):
- wherein:
- R1 to R5 are, independently, H, halo, optionally substituted C1-6alkyl, optionally substituted diazirinyl, or N3;
- R6 is H, C1-6alkyl, or C1-6alkoxy;
- and
- X is furanyl or furanyl-C1-6alk;
- or a pharmaceutically acceptable salt thereof.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.