Preparation method of sulfur-containing biphenyl compound
AssigneesShenyang Sinochem Agrochemicals R&D Co., Ltd., Jiangsu Yangnong Chemical Co., Ltd.
InventorsHaibo Yu, Hao Yang, Guimin Zhao, Zhongbao Ren, Hongfei Wu, Xueling Wang, Zeyong Zhang
Life of this patent
Estimating the term…
Abstract
A preparation method of a sulfur-containing biphenylsulfur-containing biphenyl compound shown by the general formula (I) has a reaction formula as follows: Each substituent in the formula is defined in the description. In the method, halogeno benzene shown by the general formula (II) generates a coupling reaction in a catalytic system composed of a nickel compound and at least one ligand under the combined action of metallic zinc to obtain the sulfur-containing biphenyl compound shown by the general formula (I).
Claims11
A preparation method of a sulfur-containing biphenyl compound, comprising:
- conducting a coupling reaction of a compound of formula (II) to obtain the sulfur-containing biphenyl compound of formula (I) as shown in a reaction scheme below:
- wherein R is C1-C8 alkyl or C1-C8 haloalkyl, X is bromine, and m is 0,
- wherein the reaction is carried out in a reaction mixture comprising a nickel compound, triarylphosphine, metallic zinc, and an activation additive,
- wherein the activation additive is sodium bromide,
- wherein the nickel compound is nickel chloride or nickel bromide, and
- wherein a yield of the sulfur-containing biphenyl compound is 82%-87%.
Dependencies are inferred from the claim text.