Systems and methods for high dose rate brachytherapy treatment planning using constraint optimization

A system for high-dose-rate (HDR) brachytherapy planning, comprising:

• one or more processors;
• and
• a memory storing computer instructions, the computer instructions when executed by the one or more processors cause the one or more processors to:
• obtain patient specific data of a patient, the patient specific data including information of an anatomical region of the patient having a planning target volume (PTV) and one or more organ-at-risk (OAR) regions, and indications of a plurality of clinical goals;
• determine, using the patient specific data, an optimization problem to solve for a single-fraction HDR monotherapy plan, the optimization problem including an objective function to be optimized subject to one or more first constraints on radiation doses within the one or more OAR regions and a second constraint on radiation doses within the PTV;
• optimize the objective function subject to the one or more first constraints and the second constraint;
• determine whether the single-fraction HDR monotherapy plan satisfies the one or more first constraints and the second constraint;
• update a bound value of the second constraint based on whether the single-fraction HDR monotherapy plan satisfies the one or more first constraints and the second constraint;
• and
• optimize the objective function subject to the one or more first constraints and the second constraint with the updated bound value.

A non-transitory computer-readable medium storing computer instructions, the computer instructions when executed by one or more processors cause the one or more processors to:

• obtain patient specific data of a patient, the patient specific data including information of an anatomical region of the patient having a planning target volume (PTV) and one or more organ-at-risk (OAR) regions, and indications of a plurality of clinical goals;
• determine, using the patient specific data, an optimization problem to solve for a single-fraction HDR monotherapy plan, the optimization problem including an objective function to be optimized subject to one or more first constraints on radiation doses within the one or more OAR regions and a second constraint on radiation doses within the PTV;
• optimize the objective function subject to the one or more first constraints and the second constraint;
• determine whether the single-fraction HDR monotherapy plan satisfies the one or more first constraints and the second constraint;
• update a bound value of the second constraint based on whether the single-fraction HDR monotherapy plan satisfies the one or more first constraints and the second constraint;
• and
• optimize the objective function subject to the one or more first constraints and the second constraint with the updated bound value.