UV radiation devices and methods of use thereof

A therapeutic device comprising a base component and a head component, the head component comprising a distal portion and a proximal portion, the distal portion of the head component is configured to deliver a therapeutic dose of UVC or ultraviolet A (UVA) radiation to an eye of a subject from a source of UVC or UVA radiation, and the proximal portion of the head component configured to be attached to the base component, the device further comprising:

• a proximity determining element disposed on the head component and configured to detect a predetermined distance between the source of UVC or UVA radiation and a site of treatment of the eye;
• an imaging module comprising a display that is configured to display an image of the site of treatment of the eye, wherein the display is coupled to the proximity determining element;
• and
• a signal generating element operatively connected to the display of the imaging module, wherein the display is configured to provide a visual signal upon detection of the predetermined distance by the proximity determining element and to activate the source of UVC or UVA radiation to deliver the therapeutic dose of UVC or UVA radiation to the eye of the subject,
• wherein the source of UVC or UVA radiation is configured to deliver the therapeutic dose of UVC or UVA radiation to an interior region of the eye of the subject through a light guide configured to insert into a hollow region of a vitrectomy element and enter the interior region of the eye of the subject;
• wherein:
• a) the proximity determining element comprises two or more lasers;
• or
• b) the proximity determining element is configured to activate the signal generating element upon convergence of two or more lasers;
• wherein the source of UVC or UVA radiation comprises a plurality of light emitting diodes arranged in a circular array around the proximity determining element;
• and
• wherein a wavelength of the UVC radiation is from 100 nm to 290 nm, and wherein a wavelength of the UVA radiation is from 315 nm to 380 nm.