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US 12,728,245 B2Granted
System for accessing a cochlear implant lead insertion site
AssigneeSpiral Therapeutics Inc.
InventorsHugo Peris, Benson Jung, Kevin W. Sacherman
Life of this patent
Estimating the term…
Abstract
Systems and methods can be employed for access to a middle ear for delivery of a formulation to a targeted site under direct visualization. The formulation, in some cases, can be delivered to a cochlear implant lead insertion site where a lead of a cochlear implant device enters a patient's cochlea.
Claims23
A method of delivering a self-gelling therapeutic composition at a cochlear implant lead insertion site of a cochlea, the method comprising:
- inserting a therapeutic gel delivery shaft through a transmastoid pathway toward a cochlear implant lead;
- while the therapeutic gel delivery shaft is positioned through the transmastoid pathway such that a distal port of the therapeutic gel delivery shaft is proximate to the cochlear implant lead, depositing a liquid dosage of the self-gelling therapeutic composition out of the distal port of the therapeutic gel delivery shaft onto an exterior of the cochlear implant lead at the cochlear implant lead insertion site of a round window niche of the cochlea, said self-gelling therapeutic composition comprising:
- an anti-inflammatory therapeutic agent and a polymer gel composition including water, a functional polymer of about 5% to about 15% by weight of the polymer gel composition, and a crosslinker of about 0.2% to about 0.6% by weight of the polymer gel composition, wherein the distal port of the therapeutic gel delivery shaft is sized to deposit the liquid dosage of the self-gelling therapeutic composition to output a sustained release of the anti-inflammatory therapeutic agent into the cochlea;
- and
- after said depositing the liquid dosage of the self-gelling therapeutic composition out of the distal port of the therapeutic gel delivery shaft, using direct visualization of the cochlear implant lead insertion site to verify that the self-gelling therapeutic composition is retained as a gel substance along the exterior of the cochlear implant lead at the round window niche of the cochlea.
2 more elements
A method of delivering a self-gelling therapeutic formulation at a cochlear implant lead insertion site of a cochlea, the method comprising:
- inserting a therapeutic gel delivery shaft through a transmastoid pathway toward a cochlear implant lead;
- while the therapeutic gel delivery shaft is positioned through the transmastoid pathway such that a distal port of the therapeutic gel delivery shaft is proximate to the cochlear implant lead, depositing the self-gelling therapeutic formulation out of the distal port of the therapeutic gel delivery shaft onto the cochlear implant lead insertion site at a round window niche of the cochlea, said self-gelling therapeutic formulation comprising:
- an anti-inflammatory therapeutic agent and a polymer gel composition including water, a functional polymer of about 5% to about 15% by weight of the polymer gel composition, and a crosslinker of about 0.2% to about 0.6% by weight of the polymer gel composition, wherein the distal port of the therapeutic gel delivery shaft is sized to deposit a dosage of the self-gelling therapeutic formulation to output a sustained release of the anti-inflammatory therapeutic agent into the cochlea;
- after said depositing the self-gelling therapeutic formulation out of the distal port of the therapeutic gel delivery shaft, using direct visualization of the cochlear implant lead insertion site to verify that the self-gelling therapeutic formulation is retained as a gel substance along the cochlear implant lead at the round window niche of the cochlea, wherein said depositing the self-gelling therapeutic formulation causes the self-gelling therapeutic formulation to seal the cochlear implant lead insertion site at the round window niche of the cochlea;
- and
- inserting the cochlear implant lead into the cochlea prior to said depositing the self-gelling therapeutic formulation out of the distal port of the therapeutic gel delivery shaft onto the cochlear implant lead insertion site at the round window niche of the cochlea.
3 more elements
Dependencies are inferred from the claim text.