Auto-injector device equipped with reconstitution functionality for multiple chamber drug cartridge

A handheld motor-driven drug reconstitution and auto-injector device comprising:

• a proximal drive system comprising:
• an elongated body having a substantially central longitudinal axis along said elongated body and a bore extending along said longitudinal axis and within said body the elongated body housing a controllable drive motor, and an axially drivable piston rod assembly coupled to said motor located within said bore having a distal tip;
• a distal drug cartridge holder assembly having a collapsed configuration and an extended configuration along the central longitudinal axis configured to house a multiple chamber drug cartridge comprising at least a first substance stored in a first chamber and at least a second substance stored in a second chamber, the first and second chambers being located in a nose to tall arrangement in substantial axial alignment with the central longitudinal axis wherein the distal drug cartridge holder assembly has a proximal extremity releasably attach to a distal zone of the proximal drive system, and a distal extremity configured to receive an injection needle;
• an axially fixed coupling member operably connecting the piston rod assembly to the drug cartridge holder assembly to impart rotation from the piston rod assembly to the coupling member to collapse the drug cartridge holler assembly in a proximal direction toward the distal tip of the piston rod assembly from the extended configuration along the central longitudinal axis, to the collapsed configuration along the central longitudinal axis to effect reconstitution of an injectable product comprising the at least first and second substances located within only one of said at least first or second chambers after said reconstitution and the piston rod assembly being axially movable in a distal direction relative to and along an axial length of the coupling member to move the distal tip of the piston rod assembly towards the collapsed drug cartridge holder assembly via operation of the drive motor;
• and
• a spring biasing member operably coupled to the piston rod assembly and the coupling member to bias the piston rod assembly in the proximal direction relative to the coupling member after injection, or removal of the cartridge holder assembly after reconstitution.

A handheld motor-driven drug reconstitution and auto-injector device comprising:

• a proximal drive system comprising:
• an elongated body having a substantially central longitudinal axis along said elongated body and a bore extending along said longitudinal axis and within said body the elongated body housing a controllable drive motor, and an axially drivable piston rod assembly coupled to said motor located within said bore having a distal tip;
• a distal drug cartridge holder assembly having a collapsed configuration and an extended configuration along the central longitudinal axis configured to house a multiple chamber drug cartridge comprising at least a first substance stored in a first chamber, and at least a second substance stored in a second chamber, the first and second chambers being located in a nose to tall arrangement in substantial axial alignment with the central longitudinal axis wherein the distal drug cartridge holder assembly has a proximal extremity releasably attach to a distal zone of the proximal drive system, and a distal extremity configured to receive an injection needle;
• an axially fixed coupling member having an elongated length coaxially aligned with the piston rod assembly and operably connecting the piston rod assembly to the drug cartridge holder assembly to impart rotation from the piston rod assembly to the coupling member to collapse the drug cartridge holder assembly in a proximal direction toward the distal tip of the piston rod assembly from the extended configuration along the central longitudinal axis, to the collapsed configuration along the central longitudinal axis to effect reconstitution of an injectable product comprising the at least first and second substances located within only one of said at least first or second chambers after said reconstitution and the piston rod assembly being axially movable in a distal direction relative to and along an axial length of the coupling member to move the distal tip of the piston rod assembly towards the collapsed drug cartridge holder assembly via operation of the drive motor;
• at least one projection configured for insertion into at least one elongated longitudinal slot to impart rotation from the piston rod assembly to the coupling member to collapse the drug cartridge holder assembly and the at least one projection being movable along a length of the at least one axial slot between a proximal end and a distal end of the at least one longitudinal slot for translation of the distal tip of piston rod assembly relative to the coupling member in the distal direction towards the collapsed drug cartridge holder assembly;
• and
• a biasing member operably coupled to the coupling member and the piston rod assembly to bias the at least one projection towards the proximal end of the at least one longitudinal slot and the at least one projection being moved against the biasing member along the at least one longitudinal slot to move the distal tip of the piston rod assembly in the distal direction towards the collapsed drug cartridge holder assembly.