CSF diagnostics platform
AssigneeEnClear Therapies, Inc.
InventorsRajan Patel, Gianna N. Riccardi, Kevin Kalish, Marcie Glicksman
Life of this patent
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Abstract
The present disclosure generally relates to a system for flowing a fluid, e.g., CSF, from a body of a patient for sampling and analysis. In some embodiments, the system can include a diagnostic module having one or more conduits for flowing fluid therethrough. The flow of the fluid through the valves can be regulated using a control board that changes an orientation of valves disposed in the conduits between a dead-end orientation and a flow-through orientation to sample and/or analyze the fluid from the system. In some embodiments, the fluid can be recirculated into the system through one or more of the valves, with sampling and recirculating occurring substantially simultaneously.
Claims39
A CSF management method for use with a patient having a body with CSF, the method comprising:
- forming a CSF circuit having at least one pump and catheter, the CSF circuit configured to channel the flow of the patient's CSF;
- adding a therapeutic material to the CSF circuit;
- flowing, using the pump and the catheter, the patient's CSF through the CSF circuit at one or more flow rates;
- monitoring, when CSF is flowing in the CSF circuit, at least one quality of the CSF related to the therapeutic material, the at least one quality including a concentration of the therapeutic material in the CSF, after adding the therapeutic material to the CSF;
- and
- controlling the one or more flow rates of the CSF as a function of a monitored concentration of the therapeutic material in the CSF to control absorption or distribution of the therapeutic material.
A CSF management system for use with a patient having a body with CSF and a port to the patient's CSF, the system comprising:
- a CSF circuit having a catheter and a valve system, the CSF circuit configured to control flow of the patient's CSF and being removably couplable with the patient's port to form a closed fluid flow system, the CSF circuit being accessible via a sealable port;
- a CSF monitor configured to monitor at least one quality of the CSF related to a therapeutic material, the at least one quality including a concentration of the therapeutic material in the CSF, when the CSF is flowing in the CSF circuit;
- and
- a flow controller operatively coupled with the CSF monitor, the flow controller configured to control the flow rate of the CSF through the CSF circuit as a function of a monitored concentration of the therapeutic material in the CSF to control absorption or distribution of the therapeutic material.
A medical kit comprising:
- a catheter comprising a body forming a fluid traversing bore, the body having a first end and a second end in fluid communication with the bore, the first and second ends of the body being removably couplable between first and second exterior ports of the patient, the bore being configured to be in fluid communication with both the first and second exterior ports when removably coupled therebetween, the body being configured to form a closed loop CSF channel when removably coupled between the first and second exterior ports, the CSF channel and bore being in fluid communication with the patient's subarachnoid space when the body is removably coupled;
- a valve configured to redirect fluid flow within the CSF channel;
- a CSF monitor having a sensor configured to monitor at least one quality of the CSF related to the therapeutic material within the closed loop CSF channel;
- and
- a flow controller configured to control the flow rate of the CSF through the CSF circuit as a function of a monitored concentration of the therapeutic material in the CSF to control absorption or distribution of the therapeutic material.
Dependencies are inferred from the claim text.