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US 12,728,186 B2Granted
Methods and kits for preparing pathogen-inactivated whole blood
AssigneeCerus Corporation
InventorsHarry Cahyadi, Anne North, Melissa Von Goetz, Anna Erickson
Life of this patent
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Abstract
Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.
Claims43
A kit for preparing a pathogen-inactivated whole blood composition, comprising:
- (a) a vascular access device for drawing whole blood from a donor;
- (b) a first container suitable for mixing the whole blood and a pathogen inactivation compound (PIC), wherein the first container comprises at least a first inlet and a first outlet;
- (c) a first conduit extending between the vascular access device and the first container and providing a fluid communication path for transferring the whole blood from the donor into the first container;
- (d) a container containing a pathogen inactivation compound (PIC container);
- (e) a second conduit, wherein the second conduit is coupled or configured to be coupled at one end to the PIC container, wherein the second conduit is coupled to the first container, configured to be coupled to the first container, or configured to be coupled to the first conduit, thereby providing a fluid communication path between the PIC container and the first container;
- wherein the second conduit further comprises a displacement device suitable for increasing transfer of the PIC into the first container;
- wherein the displacement device displaces air from the displacement device to facilitate the transfer of the PIC, and wherein the displacement device is separate from the PIC container;
- and
- (f) an infusion line assembly for infusing the pathogen-inactivated whole blood composition into a subject, wherein the infusion line assembly comprises a second vascular access device and an infusion line conduit that is coupled or configured to be coupled to a container of the kit.
6 more elements
A kit for preparing a pathogen-inactivated whole blood composition, comprising:
- (a) a first container suitable for mixing a whole blood composition, a pathogen inactivation compound (PIC) and a quencher, wherein the first container comprises at least a first inlet and a first outlet;
- (b) a second container suitable for storing a pathogen-inactivated whole blood composition, wherein the second container comprises at least a first inlet and a first outlet;
- (c) a container containing a pathogen inactivation compound (PIC container);
- (d) a container containing a quencher (quencher container);
- (e) a first conduit, wherein the first conduit at one end is coupled to or configured to be coupled to the PIC container and the quencher container, wherein the first conduit further comprises a displacement device suitable for increasing the transfer of the PIC and the quencher into the first container, wherein the displacement device displaces air from the displacement device to facilitate the transfer of the PIC and the quencher, and wherein the displacement device is separate from the PIC container and the quencher container;
- (f) a second conduit extending between the first container and the second container and providing a fluid communication path for transferring the whole blood composition from the first container to the second container;
- and
- (g) an infusion line assembly for infusing the pathogen-inactivated whole blood composition into a subject, wherein the infusion line assembly comprises a vascular access device and an infusion line conduit that is coupled or configured to be coupled to a container of the kit.
5 more elements
Dependencies are inferred from the claim text.