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US 12,728,175 B2Granted
Gastrin-releasing peptide receptor (GRPR)-targeted compounds and uses thereof
AssigneeAlpha-9 Oncology, Inc.
InventorsJutta Wanner, Chengcheng Zhang, Kaveh Matinkhoo, Stephen Barigye, Hsiou-Ting Kuo
Life of this patent
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Abstract
The present invention relates to gastrin-releasing peptide receptor (GRPR)-targeted compounds and their use for imaging and treatment of diseases or conditions characterized by expression of the gastrin-releasing peptide receptor.
Claims34
A compound having the structure of Compound 9:
- or a salt thereof,
- wherein the compound is optionally bound by a radiometal.
A compound having the structure of Compound 10:
- (Compound 10) or a salt thereof,
- wherein the compound is optionally bound by a radiometal.
A compound selected from:
- or a salt thereof,
- wherein the compound is optionally bound by a radiometal.
A compound having the structure of Compound 9:
- wherein the compound is bound by 177Lu.
A compound having the structure of Compound 10:
- wherein the compound is bound by 225 Ac.
Dependencies are inferred from the claim text.