Immune cell receptor antibodies conjugated to high affinity siglec-ligands
AssigneeThe Scripps Research Institute
InventorsJames C. Paulson, Maidul Islam, Fabian Pfrengle, Matthew Macauley, Shiteng Duan, Britni Arlian
Life of this patent
Estimating the term…
Abstract
Described herein are Siglec ligand-antibody conjugates and compositions thereof that are useful for suppressing unwanted immune responses such as allergies and anaphylaxis.
Claims3
A conjugate comprising at least 10 to 15 sialic acid-binding immunoglobulin-type lectins (Siglecs) ligands, each linked to an anti-receptor antibody, wherein the Siglec ligands bind to Siglec-2, Siglec-3, or Siglec-8, and wherein the anti-receptor antibody binds to a B cell receptor, a B cell receptor complex, a receptor for a Fc region of immunoglobulin E (FcεRI), or a FcεRI complex.
Dependencies are inferred from the claim text.