Use of membrane inhibitors to enhance vaccine development against enveloped viruses
AssigneeCornell University
InventorsHector Aguilar-Carreno, Isaac Monreal, David Buchholz
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Abstract
The present application relates to method of vaccinating a subject against infection by an enveloped virus. The method includes providing a compound of the Formula (I) as described herein, and contacting the compound of Formula (I) with an isolated enveloped virus, having a membrane, to inactivate the membrane of the isolated enveloped virus. The subject is then treated with the enveloped virus having an inactivated membrane to vaccinate the subject against the enveloped virus. Further disclosed is an ex vivo vaccine composition including the compound of Formula (I) and an enveloped virus.
Claims10
A method of vaccinating a subject against infection by an enveloped virus, said method comprising:
- providing a compound of the Formula (I):
- wherein
- R1 is
- or —C(O)Ph,
- R2 is C1-6 alkyl or aryl;
- R3 is C1-6 alkyl or aryl;
- R4 is C1-6 alkyl optionally substituted with aryl;
- A is C1-3 alkylene;
- X is O or NH;
- and
- is the point of attachment of R1 to S;
- contacting the compound of Formula (I) with an isolated enveloped virus, having a membrane, to inactivate the membrane of the isolated enveloped virus;
- and
- treating the subject with the enveloped virus having an inactivated membrane to vaccinate the subject against the enveloped virus.
Dependencies are inferred from the claim text.