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US 12,728,157 B2Granted
Autologous cancer tumour associated extrachromosomal circular DNA for use as a therapeutic vaccine
AssigneeCircular Biotech AB
InventorJonas Nilsson
Life of this patent
Estimating the term…
Abstract
Autologous cancer tumour associated extrachromosomal circular DNA (ecDNA) for use as a therapeutic vaccine against the cancer, and methods for preparing an autologous therapeutic vaccine.
Claims5
A method of preparing a composition comprising tumour associated extrachromosomal circular DNA (ecDNA), comprising:
- extracting total DNA content from tumour cells of a subject;
- enriching the tumour associated extrachromosomal circular DNA (ecDNA) from the extracted total DNA content;
- and
- combining the tumour associated extrachromosomal circular DNA (ecDNA) with at least one of pharmaceutically acceptable component selected from buffers, salts, preservatives, carriers, adjuvants and saponins to provide the composition comprising tumour associated extrachromosomal circular DNA (ecDNA);
- and
- administering the composition comprising tumour associated extrachromosomal circular DNA (ecDNA) to the subject.
3 more elements
A method of preparing a composition comprising tumour associated extrachromosomal circular DNA (ecDNA), comprising:
- extracting total DNA content from tumour cells of a subject;
- enriching the tumour associated extrachromosomal circular DNA (ecDNA) from the extracted total DNA content;
- delivering the enriched ecDNA to autologous antigen presenting cells ex vivo;
- and
- administering the autologous antigen presenting cells delivered with the enriched ecDNA to the subject.
2 more elements
Dependencies are inferred from the claim text.