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US 12,728,156 B2Granted
Tumor cell-derived exosomes and method of treating colorectal cancer
AssigneeRegents of the University of Minnesota
InventorsSubbaya Subramanian, Xianda Zhao
Life of this patent
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Abstract
The present invention provides tumor-derived extracellular vesicles (EVs) lacking an immune suppressive factor, for example, miR-424, methods of making and methods of use for treating cancer. Further the present invention provide vaccine compositions comprising modified tumor-derived EVs for use in treating secondary tumors.
Claims11
A composition comprising:
- modified tumor-derived extracellular vesicles (EVs) isolated from a tumor cell lacking expression of an immune suppressive factor, wherein the immune suppressive factor is miR-424, and wherein the isolated modified tumor-derived EVs are suspended in a pharmaceutically acceptable carrier;
- and one or more checkpoint inhibitor.
Dependencies are inferred from the claim text.