Liposomal nano formulation of combinational antibiotics and the uses thereof
AssigneePurdue Research Foundation
InventorsQi Zhou, Shaoning Wang
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Abstract
The present disclosure generally relates to a process for manufacturing liposomes containing polymyxin and quinolone as a treatment for bacterial infections. In particular, the present invention utilizes an anionic lipid as an essential component of a liposome for efficient encapsulation of polymyxin and quinolone, which affords a stable more efficient pharmaceutical composition for the treatment of a bacterial infection, especially infections of the lungs. Pharmaceutical compositions and methods of treatment are within the scope of this invention.
Claims10
A pharmaceutical composition comprising a polymyxin compound and a quinolone compound, or a pharmaceutically acceptable salt thereof, respectively, a phosphatidylcholine (PC), an anionic lipid and cholesterol, wherein polymyxin and quinolone, or a pharmaceutically acceptable salt thereof, respectively, are encapsulated into or on a liposome formed by said PC, anionic liquid and cholesterol, and wherein said PC and said anionic lipid are in a ratio of about 1:20 to about 20:1 mol/mol, and the polymyxin to quinolone compound ratio is from about 1:10 to about 10:1 mol/mol.
Dependencies are inferred from the claim text.