Methods of treating multiple sclerosis

A method of treating a patient suffering from early-stage multiple sclerosis (ESMS), the method comprising:

• determining an expanded disability status scale (EDSS) score of the patient;
• identifying the patient as having ESMS in the case that the patient has an EDSS score that is ≤3.0;
• and
• administering ponesimod to the patient using a regimen that is effective to reduce the number of combined unique active lesions (CUALs) in the patient by at least 50%, relative to a patient population at substantially the same level of disease progression receiving a standard of care treatment that does not comprise ponesimod.

A method of treating a patient suffering from early-stage multiple sclerosis (ESMS), the method comprising:

• determining an expanded disability status scale (EDSS) score of the patient;
• identifying the patient as having ESMS in the case that the patient has an EDSS score that is ≤3.0;
• and
• administering ponesimod to the patient using a regimen that is effective to reduce the annualized relapse rate (ARR) in the patient by at least 25%, relative to a patient population at substantially the same level of disease progression receiving a standard of care treatment that does not comprise ponesimod.

A method of treating a patient suffering from early-stage multiple sclerosis (ESMS) and fatigue, the method comprising:

• determining an expanded disability status scale (EDSS) score of the patient;
• identifying the patient as having ESMS in the case that the patient has an EDSS score that is ≤3.0;
• and
• administering ponesimod to the patient using a regimen that is effective to reduce MS-fatigue mean difference to about −4%, relative to a patient population at substantially the same level of disease progression receiving a standard of care treatment that does not comprise ponesimod.