Compounds for the treatment of bacterial infections and potentiation of antibiotics

A pharmaceutical composition comprising a compound of Formula VI:

• or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier, in combination with an effective amount of an antibacterial antibiotic for treating a bacterial infection in a host in need thereof wherein:
• R3 is independently at each occurrence selected from the group consisting of hydrogen, hydroxyl, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkanoyl, carbocyclic, C2-C6alkenyl, C2-C6alkynyl, heteroaryl, aryl, heterocyclyl, —COOR, —C(O)R, fluorine, chlorine, bromine, and iodine
• R9 and R12 are independently at each occurrence selected from the group consisting of hydrogen, hydroxyl, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkanoyl, aliphatic, carbocyclic, C1-C6hydroxyalkyl, C1-C6haloalkyl, N(R3)2, —NHSO2alkyl, —N(alkyl) SO2alkyl, —NHSO2aryl, —N(alkyl)SO2aryl, —NHSO2alkenyl, —N(alkyl)SO2alkenyl, —NHSO2alkynyl, —N(alkyl)SO2alkynyl, NO2, —COOH, —CONH2, —P(O)(OH)2, —S(O)R3, —SO2R3, —SO3R3, —SO2N(R3)2, —OSO2R3, —N(R3)SO2R3, azide, aryl, heteroaryl, heterocyclyl, fluorine, chlorine, bromine, iodine, thiol, and cyano;
• and
• R10 and R11 are independently at each occurrence selected from the group consisting of hydroxyl, C1-C6alkanoyl, carbocyclic, C1-C6hydroxyalkyl, C1-C6haloalkyl, N(R3)2, —NHSO2alkyl, —N(alkyl)SO2alkyl, —NHSO2aryl, —N(alkyl)SO2aryl, —NHSO2alkenyl, —N(alkyl)SO2alkenyl, —NHSO2alkynyl, —N(alkyl)SO2alkynyl, NO2, —COOH, —CONH2, —C(O)R, —P(O)(OH)2, —S(O)R3, —SO2R3, —SO3R3, —SO2N(R3)2, —OSO2R3, —N(R3)SO2R3, azide, aryl, heteroaryl, heterocyclyl, fluorine, bromine, iodine, thiol, and cyano;
• wherein at least one of R10 or R11 is not fluorine.