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US 12,728,102 B2Granted
Transdermal patch of a portable ultrasound-generating system for improved delivery of therapeutic agents and associated methods of treatment
AssigneeNanoVibronix Inc
InventorBrian Murphy
Life of this patent
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Abstract
A portable surface acoustic wave (SAW)-generating system, a transdermal patch, and methods of treatment with improved transdermal administration of drugs are provided. Application of the transdermal patch comprising a therapeutically effective amount of the cannabis id, such as a cannabis drug, to the skin in combination with SAW results in a synergistic effect on delivery and absorption of the at least one drug as compared to topical administration of the drug via the transdermal patch without the surface acoustic waves generated by the portable SAW-generating system.
Claims14
A transdermal patch, comprising:
- an impermeable layer forming an upper surface of the transdermal patch;
- a first drug layer comprising a first pharmaceutical composition comprising a cannabis drug and at least one pharmaceutically acceptable excipient, the cannabis drug being a cannabinoid selected from the group consisting of tetrahydrocannabinol (THC), cannabinol (CB), cannabidiol (CBD), and cannabichromene (CBC), and is present in an amount therapeutically effective for treating or alleviating acute or chronic pain associated with a disease or condition of a subject;
- an adhesive layer forming at least a portion of a lower surface of the transdermal patch, the adhesive layer being configured to allow passage of the first pharmaceutical composition from the first drug layer to the skin of the subject;
- a removable protective layer disposed on a lower surface of the adhesive layer;
- an actuator with an integrated piezo transducer located on a lower surface of the transdermal patch such that a metal surface of the transducer faces a direction of adhesion of the transdermal patch.
2 more elements
Dependencies are inferred from the claim text.