Method of preparing hyaluronic acid nanoparticles
AssigneeAmorepacific Corporation
InventorsHyuk Kim, Chaeyeon Song, Joonho Choi
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Abstract
The present disclosure relates to a method for preparing hyaluronic acid nanoparticle and to hyaluronic acid nanoparticle prepared by the method. In one aspect of the present disclosure, the method for preparing hyaluronic acid nanoparticle can minimize the size of the hyaluronic acid nanoparticle, and the hyaluronic acid nanoparticle prepared by the method has low viscosity characteristics and is excellent in spreadability, and can penetrate the stratum corneum evenly when applied to the skin.
Claims9
A method for preparing a skin penetration formulation comprising hyaluronic acid nanoparticles, comprising performing nanoparticulation of a starting hyaluronic acid by a ultra-high pressure dispersion to obtain the hyaluronic acid nanoparticles, wherein the ultra-high pressure dispersion is performed under a pressure condition of 130 to 250 MPa,
- wherein a molecular weight of the starting hyaluronic acid and a molecular weight of hyaluronic acid of the hyaluronic acid nanoparticles have a difference of 100,000 Da or less, and
- wherein the ultra-high pressure dispersion is performed repeatedly 11 or more times.
Dependencies are inferred from the claim text.