Pharmaceutical composition comprising enzalutamide
AssigneeSynthon BV
InventorsSara Fradera Gelabert, Lisardo Alvarez Fernandez, Rohit Kumar
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Abstract
The present invention relates to a tablet composition comprising a granulate consisting of a co-precipitate on a substrate, wherein the co-precipitate comprises enzalutamide in amorphous form and a cellulosic concentration enhancing polymer. The invention further relates to the use of said composition as a medicament, particularly in the treatment of castration-resistant prostate cancer.
Claims15
A tablet composition comprising a granulate consisting of a co-precipitate on a substrate, wherein the co-precipitate comprises enzalutamide in amorphous form and a cellulosic concentration enhancing polymer;
- wherein said granulate was obtained by spraying a solution comprising the enzalutamide and the cellulosic concentration enhancing polymer over the substrate and subsequently drying to obtain said co-precipitate on the substrate;
- wherein said cellulosic concentration enhancing polymer is selected from hydroxylpropylmethylcellulose acetate succinate (HPMCAS) and hydroxypropylmethylcellulose phthalate (HPMCP);
- wherein the substrate comprises a sugar alcohol, microcrystalline cellulose, or mixtures thereof.
Dependencies are inferred from the claim text.