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US 12,728,093 B2Granted
Oromucosal therapeutic system containing an adhesive layer
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsMarlene Fuhrmann, Marius Bauer
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Abstract
The present invention relates to oromucosal therapeutic systems comprising a backing layer, an adhesive layer, and an active agent-containing layer, such oromucosal therapeutic systems for use in a method of treatment and/or prophylaxis, processes of manufacture of such oromucosal therapeutic systems as well as adhesive layers and bi-layer laminates for such oromucosal therapeutic systems.
Claims17
An oromucosal therapeutic system for the oromucosal administration of an active agent comprising
- a mucoadhesive layer structure comprising
- A) a backing layer comprising a first film-forming polymer,
- B) an adhesive layer comprising
- a laminating adhesive;
- and
- a first plasticizer, and
- C) an active agent-containing layer comprising a second film-forming polymer,
- wherein
- the laminating adhesive is a mixture comprising polyvinylpyrrolidone and polyvinylacetate,
- wherein the polyvinylacetate has a molecular weight of from 400,000 to 500,000, and
- the first plasticizer is selected from the group consisting of mono-, di-, oligo- and polysaccharides and derivatives thereof, triacetin, triethyl citrate, tributyl citrate, propylene glycol, glycerin, medium chain triglycerides and any mixture thereof.
8 more elements
Dependencies are inferred from the claim text.