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US 12,727,930 B2Granted
Systems, devices, and methods for ablation and defunctionalization of a gallbladder
AssigneeIctero Medical, Inc.
InventorsMatthew Nojoomi, David Waters, Aedan Mangan, Eric Ryba, Michael Mulanix
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Abstract
Provided herein are catheter devices, systems, and methods to ablate a tissue location. The devises, systems, and methods disclosed herein include ablation systems including a catheter system with inner and outer shafts that deliver an ablation medium (e.g., a cryogenic ablation medium) to a body lumen and evacuate the ablation medium from the body lumen. In some embodiments, devices, systems, and methods disclose herein include expandable structures that facilitate in positioning of nozzles and/or evacuation of ablation medium from a body lumen.
Claims6
A method, comprising:
- transitioning a first expandable body disposed on a distal end of a first shaft into an expanded configuration to retain the distal end of the first shaft within a gallbladder lumen of a subject, the first shaft defining a first lumen;
- advancing a distal portion of a second shaft through the first lumen and into the gallbladder lumen, the second shaft defining a second lumen that terminates at a plurality of nozzle openings disposed on the distal portion of the second shaft;
- transitioning a second expandable body disposed on the distal portion of the second shaft into a deployed configuration to position the plurality of nozzle openings at a minimum radial distance away from a wall of the gallbladder lumen;
- delivering, via the second lumen and the plurality of nozzle openings, and after transitioning the second expandable body, a cryogenic ablation medium into the gallbladder lumen such that the cryogenic ablation medium can contact and ablate the wall of the gallbladder lumen;
- evacuating, via an evacuation path defined in part by one or both of the first and second shafts, fluids from within the gallbladder lumen while delivering the cryogenic ablation medium;
- measuring an intraluminal pressure of the gallbladder lumen via a pressure sensor operatively coupled to a pressure sensing lumen defined within the first shaft, the pressure sensing lumen having a distal opening that is communicatively coupled to the gallbladder lumen when the distal end of the first shaft is disposed in the gallbladder lumen;
- controlling the delivery of the cryogenic ablation medium based on the intraluminal pressure of the gallbladder lumen;
- and
- heating, using a heating element, at least a portion of the evacuation path to reduce formation of ice within the evacuation path.
6 more elements
A method, comprising:
- transitioning a retention mechanism disposed on a distal end of an introducer into an expanded configuration to retain a distal tip of an introducer within a gallbladder of a subject;
- advancing a distal end of an ablation catheter into the gallbladder via a lumen of the introducer, the ablation catheter defining a second lumen and including a plurality of nozzle openings and an expandable body disposed on the distal end of the ablation catheter, the expandable body formed of a plurality of elongate members;
- transitioning the expandable body into a deployed configuration such that the plurality of elongate members expand outward from a longitudinal axis of the ablation catheter to position the plurality of nozzle openings at least a predetermined distance from a wall of the gallbladder;
- conveying, via the second lumen, a cryogenic ablation fluid to the plurality of nozzle openings;
- dispensing the cryogenic ablation fluid from the plurality of nozzle openings in a spray pattern to cause the cryogenic ablation fluid to contact the wall of the gallbladder and phase change into a cryogenic ablation gas;
- measuring an intraluminal pressure of the gallbladder via a pressure sensor operatively coupled to a pressure sensing lumen defined within the ablation catheter, the pressure sensing lumen having a distal opening that is communicatively coupled to the gallbladder when the distal end of the ablation catheter is disposed in the gallbladder;
- and
- controlling the dispensing of the cryogenic ablation fluid based on the intraluminal pressure of the gallbladder lumen.
5 more elements
Dependencies are inferred from the claim text.