Systems and methods for uterine peristalsis imaging

A system for monitoring uterine peristalsis of a non-pregnant uterus of a mammal during at least one uterine contraction, the system comprising:

• a first patch operable to be secured to a plurality of locations on a body surface, the first patch associated with a plurality of imaging markers;
• a first imaging modality of the uterus of the mammal, wherein the first imaging modality generates a first set of three-dimensional images representing the body surface and uterus of the mammal;
• a second patch operable to replace the first patch at the plurality of locations on the body surface, wherein the first patch is removed before applying the second patch to the plurality of locations;
• a second imaging modality of the uterus of the mammal, the second imaging modality associated with an optical scanner, wherein the second imaging modality generates a second set of three-dimensional images representing the body surface and uterus of the mammal;
• an electrical recording device in electrical communication with the second patch, the electrical recording device configured to record body surface electrical potentials during the uterine contraction and to record a plurality of electrical signals on the body surface surrounding the uterus of the mammal during the uterine contraction;
• a third imaging modality of the uterus of the mammal, wherein the third imaging modality generates a set of two-dimensional images representing the body surface and uterus of the mammal;
• identifying a body-uterus geometry of the mammal based on at least one of the first and second set of generated three-dimensional images and the set of generated two-dimensional images;
• and
• at least one non-transitory computer readable medium storing instructions which when executed by at least one processor, cause the at least one processor to:
• receive the first set of generated three-dimensional images from the first imaging modality;
• determine the plurality of locations based on the imaging markers visible in the first set of generated three-dimensional images;
• receive the second set of generated three-dimensional images from the second imaging modality;
• receive the set of generated two-dimensional images from the third imaging modality;
• determine a body-uterus geometry of the mammal based on the first and second sets of three-dimensional images, the set of two-dimensional images, and the plurality of locations;
• receive the plurality of electrical signals from the electrical recording device;
• and
• generate at least one of a body surface electrical potential map based on the body-uterus geometry and the plurality of electrical signals.

A method for monitoring uterine peristalsis of a non-pregnant uterus of a mammal during at least one uterine contraction, the mammal having a body surface surrounding the uterus, the method comprising:

• applying a plurality of imaging markers to a plurality of locations on the body surface, each one of the plurality of imaging markers applied to one of the plurality of locations;
• performing a first imaging scan of the uterus of the mammal, the first imaging scan operable to generate a first plurality of generated three-dimensional images of the body surface and uterus of the mammal;
• determining a first body-uterus geometry of the mammal based on the first plurality of generated three-dimensional images;
• replacing each one of the plurality of imaging markers applied to one of a plurality of locations, with one of a plurality of electrodes, each one of the plurality of electrodes associated with a second imaging scan and an electrical recording device;
• performing the second imaging scan of the uterus of the mammal, the second imaging scan operable to generate a second plurality of generated three-dimensional images of the body surface and uterus of the mammal;
• determining a second body-uterus geometry of the mammal based on the second plurality of generated three-dimensional images;
• recording body surface electrical potentials via the electrical recording device during the at least one uterine contraction, the recording device in electrical communication with the plurality of electrodes;
• performing a third imaging scan of the uterus of the mammal, the third imaging scan operable to generate a plurality of generated two-dimensional images of the body surface and uterus of the mammal;
• generating a plurality of body surface electrical potential maps based on at least one of the first and second body-uterus geometries, the plurality of generated two-dimensional images, and the plurality of body surface electrical potentials detected at the plurality of locations during the at least one uterine contraction;
• and
• reconstructing at least one of the first and second plurality of generated three-dimensional images to provide a plurality of reconstructed three-dimensional images representative of uterine peristalsis electrical activity of the uterus of the mammal during the at least one uterine contraction from the body-uterus geometry of the mammal and the plurality of body surface electrical potentials.