Dosimetry system for photodynamic anitmicrobial therapy device of infectious keratitis

A dosimetry system comprising:

• a variable optical filter system configured to:
• receive a second light, the second light comprising luminescence produced by singlet oxygen and one or more background signals, each of which are based on irradiating a sample with a first light comprising a first wavelength within an excitation range of a photosensitizer applied to the sample, wherein activating the photosensitizer produces the singlet oxygen, and
• selectively transmit the luminescence and the one or more background signals as a third light, the variable optical filter system comprising a plurality of optical bandpass filters that are switchable to selectively transmit the luminescence and the one or more background signals;
• a photoreceiver configured to receive the third light and configured to generate electrical output signals corresponding to the luminescence and the one or more background signals, the electrical output signals being indicative of an amount of the singlet oxygen produced based on activating the photosensitizer;
• and
• a controller communicatively coupled to the photoreceiver and configured to receive the electrical output signals from the photoreceiver, determine a number of molecules of the singlet oxygen, produced by activating the photosensitizer with the first light, based on the electrical output signals, and generate a dosage measurement based on the determined number of molecules of the singlet oxygen.