US 12,725,770 B2 · Methods for performing charge detection mass spectrometry with temporal resolution

Abstract

A process for charge detection mass spectrometry includes acquiring a time-varying signal representative of a current induced on a detector by oscillatory motion of an ion within a trapping region; processing the time-varying signal to derive a frequency of the oscillatory motion; generating, based on the amplitude of the time-varying signal and the derived frequency of the oscillatory motion, Selective Temporal Overview of Resonant Ion (STORI) data representing STORIreal values versus time and STORIimag values versus time; regenerating the STORI data based on a variation of the frequency of the oscillatory motion over time; and determining a charge state of the ion based on the regenerated STORI data.

Claims20

Dependent claims

A non-transitory computer-readable medium storing instructions that, when executed, direct at least one processor of a computing device for mass spectrometry to perform a process comprising:

acquiring a time-varying signal representative of a current induced on a detector by oscillatory motion of an ion within a trapping region;
processing the time-varying signal to derive a frequency of the oscillatory motion;
generating, in accordance with equations (1) and (2), Selective Temporal Overview of Resonant Ion (STORI) data representing STORIreal values versus time and STORIimag values versus time:
STORI
real
(
t
n
)
=
S
⁡
(
t
n
)
*
cos
⁡
(
ω
*
t
n
)
+
STORI
real
(
t
n
-
1
)
(
1
)
STORI
imag
(
t
n
)
=
-
S
⁡
(
t
n
)
*
sin
⁡
(
ω
*
t
n
)
+
STORI
imag
(
t
n
-
1
)
(
2
)
where S(tn) is amplitude of the time-varying signal and ω is the derived frequency of the oscillatory motion;
regenerating the STORI data based on a variation of the frequency of the oscillatory motion over time;
and
determining a charge state of the ion based on the regenerated STORI data.

73 more elements

A system for determining a charge state of an ion, comprising:

one or more processors;
and
memory storing executable instructions that, when executed by the one or more processors, cause a computing device to perform a process comprising:
acquiring a time-varying signal representative of a current induced on a detector by oscillatory motion of an ion within a trapping region;
processing the time-varying signal to derive a frequency of the oscillatory motion;
generating, in accordance with equations (1) and (2), Selective Temporal Overview of Resonant Ion (STORI) data representing STORIreal values versus time and STORIimag values versus time:
STORI
real
(
t
n
)
=
S
⁡
(
t
n
)
*
cos
⁡
(
ω
*
t
n
)
+
STORI
real
(
t
n
-
1
)
(
1
)
STORI
imag
(
t
n
)
=
-
S
⁡
(
t
n
)
*
sin
⁡
(
ω
*
t
n
)
+
STORI
imag
(
t
n
-
1
)
(
2
)
where S(tn) is amplitude of the time-varying signal and o is the derived frequency of the oscillatory motion;
regenerating the STORI data based on a variation of the frequency of the oscillatory motion over time;
and
determining a charge state of the ion based on the regenerated STORI data.

76 more elements

Dependencies are inferred from the claim text.

Methods for performing charge detection mass spectrometry with temporal resolution

Life of this patent

Methods for performing charge detection mass spectrometry with temporal resolution

Life of this patent

Abstract

Claims20