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US 12,723,328 B2Granted
HBV specific TCR library and its use as personalised medicine
AssigneeLion TCR Pte. Ltd.
InventorsAntonio Bertoletti, Zi Zong Ho, Sarene Koh, Anthony Tanoto Tan, Lu-En Wai
Life of this patent
Estimating the term…
Abstract
The invention provides T cell receptors (TCRs) that bind Hepatitis B virus (HBV) antigens. The present invention also provides methods of producing, screening and selecting the TCRs, therapeutic applications of the TCRs, and libraries of the TCRs.
Claims6
A library of T cell receptors (TCRs), wherein the TCR library comprises at least 26 TCRs, wherein the TCR library includes TCRs that have CDR3a and CDR3b sequences that respectively correspond to each CDR3a/CDR3b pairing of the following list:
- CDR3a:
- (SEQ ID NO:
- 1)
- AETLDNYGQNFV
- and
- CDR3b:
- (SEQ ID NO:
- 18)
- SAVDRDEPFHSNQPQH;
- CDR3a:
- (SEQ ID NO:
- 2)
- ATWLSGSARQLTF
- and
- CDR3b:
- (SEQ ID NO:
- 19)
- ASSNRASSYNEQF;
- CDR3a:
- (SEQ ID NO:
- 3)
- AVNLYAGNMLT
- and
- CDR3b:
- (SEQ ID NO:
- 20)
- ASSSDFGNQPQH;
- CDR3a:
- (SEQ ID NO:
- 4)
- CGADRGGGKLIF
- and
- CDR3b:
- (SEQ ID NO:
- 21)
- CASSLFKGADTQYF;
- CDR3a:
- (SEQ ID NO:
- 5)
- CAYRSGLNNDMRF
- and
- CDR3b:
- (SEQ ID NO:
- 22)
- CASSLELAGPWGNEQFF;
- CDR3a:
- (SEQ ID NO:
- 6)
- AVSDNQGGKLI
- and
- CDR3b:
- (SEQ ID NO:
- 23)
- ASSLSAAYEQY;
- CDR3a:
- (SEQ ID NO:
- 7)
- CAVRYNNARLMF
- and
- CDR3b:
- (SEQ ID NO:
- 24)
- CSAPAGMGYEQYF;
- CDR3a:
- (SEQ ID NO:
- 8)
- CVVNGVDSSYKLIF
- and
- CDR3b:
- (SEQ ID NO:
- 25)
- CASEMAGGGDNYGYTF;
- CDR3a:
- (SEQ ID NO:
- 9)
- CLVGDEDTGRRALTF
- and
- CDR3b:
- (SEQ ID NO:
- 26)
- CASSFSGKASYYEQYF;
- CDR3a:
- (SEQ ID NO:
- 10)
- CAVRDQTGANNLFF
- and
- CDR3b:
- (SEQ ID NO:
- 27)
- CASSPEPTSGSFNEQFF;
- CDR3a:
- (SEQ ID NO:
- 11)
- CAVNMVAGNMLTF
- and
- CDR3b:
- (SEQ ID NO:
- 28)
- CASSPDSSGANVLTF;
- CDR3a:
- (SEQ ID NO:
- 12)
- CAVDGNNRLAF
- and
- CDR3b:
- (SEQ ID NO:
- 29)
- CSVDMDWGIGGYTF;
- CDR3a:
- (SEQ ID NO:
- 13)
- CAGAGYGGSQGNLIF
- and
- CDR3b:
- (SEQ ID NO:
- 30)
- CASSIAGGAEQYF;
- CDR3a:
- (SEQ ID NO:
- 14)
- CAYIGNAGNMLTF
- and
- CDR3b:
- (SEQ ID NO:
- 31)
- CASSLSYRGLGEQFF;
- CDR3a:
- (SEQ ID NO:
- 15)
- CAVYHTGFQKLVF
- and
- CDR3b:
- (SEQ ID NO:
- 32)
- CASSSRQGGTYEQYF;
- CDR3a:
- (SEQ ID NO:
- 16)
- CAESMGDFNKFYF
- and
- CDR3b:
- (SEQ ID NO:
- 33)
- CASSPGEGNQPQHF;
- CDR3a:
- (SEQ ID NO:
- 17)
- CAVSTNFGNEKLTF
- and
- CDR3b:
- (SEQ ID NO:
- 34)
- CASSASLADNTGELFF,
- CDR3a:
- (SEQ ID NO:
- 151)
- CAESTGGSYIPTF
- and
- CDR3b:
- (SEQ ID NO:
- 160)
- CASASDSDDEKLFF,
- CDR3a:
- (SEQ ID NO:
- 152)
- CAVNAPGGYNKLIF
- and
- CDR3b:
- (SEQ ID NO:
- 161)
- CASSISQGGYGYTF,
- CDR3a:
- (SEQ ID NO:
- 153)
- CAVERPTGGYNKLIF
- and
- CDR3b:
- (SEQ ID NO:
- 162)
- CASSPGTDYEQYF,
- CDR3a:
- (SEQ ID NO:
- 154)
- CAVEDYGQNFVF
- and
- CDR3b:
- (SEQ ID NO:
- 163)
- CSARDLSGRSLDTQYF,
- CDR3a:
- (SEQ ID NO:
- 155)
- CALSDSSGGSYIPTF
- and
- CDR3b:
- (SEQ ID NO:
- 164)
- CASSLGRQTNTEAFF,
- CDR3a:
- (SEQ ID NO:
- 156)
- CAACYSGYALNF
- and
- CDR3b:
- (SEQ ID NO:
- 165)
- CASSYRPKLDTEAFF,
- CDR3a:
- (SEQ ID NO:
- 157)
- CAVVTNDYKLSF
- and
- CDR3b:
- (SEQ ID NO:
- 166)
- CASSQDLGQGSDTQYF,
- CDR3a:
- (SEQ ID NO:
- 158)
- CAMRSFAQAGTALIF
- and
- CDR3b:
- (SEQ ID NO:
- 167)
- CASSQRGKGQGDEETQYF,
- and
- CDR3a:
- (SEQ ID NO:
- 159)
- CAGWISPQGAQKLVF
- and
- (SEQ ID NO:
- 168)
- CDR3b:
- CASSLSTNTEAFF,
- such that each listed CDR3a/CDR3b pairing is present in the TCR library;
- and/or wherein the TCR library includes TCRs that have CDR3a and CDR3b sequences that respectively correspond to each pairing set forth in the above list, in which one or two amino acids are replaced with another amino acid, such that each CDR3a/CDR3b pairing is present with up to one or two amino acid substitutions in the TCR library.
234 more elements
Dependencies are inferred from the claim text.