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US 12,723,106 B2Granted
Protease-processed molecules
AssigneeSanofi
InventorsThomas Langer, Ercole Rao, Sandra Weil
Life of this patent
Estimating the term…
Abstract
The present invention relates to protein molecules comprising at least one protease-cleavable linker. It also relates to protein molecules obtainable by protease-cleavage of such protein molecules and their use in therapy.
Claims26
A protein comprising at least one polypeptide chain having the formula
- PP1-PCL-PP2,
- wherein
- PP1 is a first polypeptide,
- PP2 is a second polypeptide, and
- PCL is a furin and/or furin-like protease-cleavable linker comprising at least one furin and/or furin-like protease-cleavage site comprising the amino acid sequence HRRX1X2RSVDE (SEQ ID NO:
- 42),
- wherein X1 and X2 are independently selected from the group consisting of KK, KQ, KR, QK, QQ, QR, RK, RQ and RR.
4 more elements
Dependencies are inferred from the claim text.