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US 12,723,103 B2Granted
Hot-start antibodies for Taq DNA polymerase variant
AssigneeWatchmaker Genomics, Inc.
InventorsPhillip Venter, Bjarne Faurholm, Eric van der Walt
Life of this patent
Estimating the term…
Abstract
This disclosure relates to Taq polymerase binding antibody compositions and methods of use for nucleic acid amplification.
Claims18
An antibody that binds to a Taq polymerase, wherein the antibody comprises:
- (i) a heavy chain comprising a heavy chain variable region (VH);
- and
- (ii) a light chain comprising a light chain variable region (VL);
- wherein the VH comprises a heavy chain complementarity determining region 1 (CDR-H1) comprising an amino acid sequence as set forth in SEQ ID NO:
- 3, a heavy chain complementarity determining region 2 (CDR-H2) comprising an amino acid sequence as set forth in SEQ ID NO:
- 4, a heavy chain complementarity determining region 3 (CDR-H3) comprising an amino acid sequence as set forth in SEQ ID NO:
- 5;
- and
- wherein the VL comprises a light chain complementarity determining region 1 (CDR-L1) comprising an amino acid sequence as set forth in SEQ ID NO:
- 6, a light chain complementarity determining region 2 (CDR-L2) comprising an amino acid sequence as set forth in SEQ ID NO:
- 7, and a light chain complementarity determining region 3 (CDR-L3) comprising an amino acid sequence as set forth in SEQ ID NO:
- 8.
9 more elements
Dependencies are inferred from the claim text.