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US 12,723,100 B2Granted
Nectin-4 antibodies and uses thereof
AssigneeCspc Megalith Biopharmaceutical Co., Ltd.
InventorsYi Pei, Haichun Huang, Ming Lei, Han Li
Life of this patent
Estimating the term…
Abstract
The present disclosure provides antibodies and antibody fragments thereof that bind to Nectin-4. Such antibodies and antibody fragments are useful for the treatment of cancer, either alone or in combination with other agents.
Claims20
An anti-Nectin-4 antibody or an antigen-binding fragment thereof comprising a variable heavy (VH) region and a variable light (VL) region, wherein the VH region and the VL region comprise a set of CDRs selected from:
- (a) VH:
- CDR1:
- SEQ ID NO:
- 17, CDR2:
- SEQ ID NO:
- 18, CDR3:
- SEQ ID NO:
- 19;
- VL:
- CDR1:
- SEQ ID NO:
- 20, CDR2:
- SEQ ID NO:
- 21, CDR3:
- SEQ ID NO:
- 22;
- (b) VH:
- CDR1:
- SEQ ID NO:
- 23, CDR2:
- SEQ ID NO:
- 24, CDR3:
- SEQ ID NO:
- 25;
- VL:
- CDR1:
- SEQ ID NO:
- 26, CDR2:
- SEQ ID NO:
- 27, CDR3:
- SEQ ID NO:
- 28;
- (c) VH:
- CDR1:
- SEQ ID NO:
- 29, CDR2:
- SEQ ID NO:
- 30, CDR3:
- SEQ ID NO:
- 31;
- VL:
- CDR1:
- SEQ ID NO:
- 32, CDR2:
- SEQ ID NO:
- 33, CDR3:
- SEQ ID NO:
- 34;
- (d) VH:
- CDR1:
- SEQ ID NO:
- 35 CDR2:
- SEQ ID NO:
- 36, CDR3:
- SEQ ID NO:
- 37;
- VL:
- CDR1:
- SEQ ID NO:
- 38, CDR2:
- SEQ ID NO:
- 39, CDR3:
- SEQ ID NO:
- 40;
- (e) VH:
- CDR1:
- SEQ ID NO:
- 41, CDR2:
- SEQ ID NO:
- 42, CDR3:
- SEQ ID NO:
- 43;
- VL:
- CDR1:
- SEQ ID NO:
- 44, CDR2:
- SEQ ID NO:
- 45, CDR3:
- SEQ ID NO:
- 46;
- (f) VH:
- CDR1:
- SEQ ID NO:
- 47, CDR2:
- SEQ ID NO:
- 48, CDR3:
- SEQ ID NO:
- 49;
- VL:
- CDR1:
- SEQ ID NO:
- 50, CDR2:
- SEQ ID NO:
- 51, CDR3:
- SEQ ID NO:
- 52;
- (g) VH:
- CDR1:
- SEQ ID NO:
- 47, CDR2:
- SEQ ID NO:
- 53, CDR3:
- SEQ ID NO:
- 54;
- VL:
- CDR1:
- SEQ ID NO:
- 55, CDR2:
- SEQ ID NO:
- 56, CDR3:
- SEQ ID NO:
- 52;
- or
- (h) VH:
- CDR1:
- SEQ ID NO:
- 57, CDR2:
- SEQ ID NO:
- 58, CDR3:
- SEQ ID NO:
- 59;
- VL:
- CDR1:
- SEQ ID NO:
- 50, CDR2:
- SEQ ID NO:
- 51, CDR3:
- SEQ ID NO:
- 60.
126 more elements
Dependencies are inferred from the claim text.