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US 12,723,094 B2Granted
Anti-DR5 polypeptides and methods of use thereof
AssigneeRegents of the University of Minnesota
InventorsBenjamin Hackel, Jonathan N. Sachs, Nagamani Vunnam
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Abstract
Certain embodiments of the invention provide helix sequences that have affinity for Death Receptor 5 (DR5). Certain embodiments of the invention provide an isolated anti-DR5 polypeptide (e.g., affibody for DR5) that modulates the activity and/or conformation of DR5. Certain embodiments of the invention provide methods of noncompetitively inhibiting DR5 and/or treating a fatty liver disorder.
Claims20
An isolated anti-Death Receptor 5 (DR5) polypeptide, comprising one or more helix domains selected from the group consisting of:
- (a) a helix 1 sequence comprising the amino acid sequence of any one of SEQ ID NOs:
- 1 to 6;
- and
- (b) a helix 2 sequence comprising the amino acid sequence of any one of SEQ ID NOs:
- 7 to 12.
2 more elements
An isolated anti-DR5 polypeptide, comprising:
- (a) a helix 1 sequence comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:6;
- and
- (b) a helix 2 sequence comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 12.
1 more element
Dependencies are inferred from the claim text.