4-1BBL trimer-containing antigen binding molecules

A 4-1BBL trimer-containing antigen binding molecule comprising

• (a) a first heavy chain comprising the amino acid sequence of SEQ ID NO:29, a first light chain comprising the amino acid sequence of SEQ ID NO:30, a second heavy chain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:21 and a second light chain comprising an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO:22;
• wherein
• the second heavy chain comprises a heavy chain variable region (VH) comprising complementarity determining regions (CDR) comprising
• (i) CDR-H1 comprising the amino acid sequence of SEQ ID NO:
• 13,
• (ii) CDR-H2 comprising the amino acid sequence of SEQ ID NO:
• 14, and
• (iii) CDR-H3 comprising the amino acid sequence of SEQ ID NO:
• 15;
• and the second light chain comprises a light chain variable region (VL) comprising
• (iv) CDR-L1 comprising the amino acid sequence of SEQ ID NO:
• 16,
• (v) CDR-L2 comprising the amino acid sequence of SEQ ID NO:
• 17, and
• (vi) CDR-L3 comprising the amino acid sequence of SEQ ID NO:
• 18;
• or (b)
• (i) a first heavy chain comprising the VH domain comprising the amino acid sequence of SEQ ID NO:
• 19 and a first light chain comprising the VL domain comprising the amino acid sequence of SEQ ID NO:20,
• (ii) a second heavy chain comprising the amino acid sequence selected from the group consisting of SEQ ID NO:21, SEQ ID NO:25 and SEQ ID NO:27, and
• (iii) a second light chain comprising the amino acid sequence selected from the group consisting of SEQ ID NO:22, SEQ ID NO:26 and SEQ ID NO:28.