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US 12,723,081 B2Granted
In situ thiol-maleimide crosslinked hydrogel for immune checkpoint blockade delivery
AssigneeGeorgia Tech Research Corporation
InventorsSusan Napier Thomas, Jihoon Kim
Life of this patent
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Abstract
Disclosed are hydrogel compositions that can be used to deliver therapeutic agents, including therapeutic proteins, to patients in need thereof. In an embodiment, the therapeutic agent is an immune checkpoint blockade antibody, and the hydrogel is a thermoresponsive polymer crosslinked with a hydrophilic polymer.
Claims20
A hydrogel composition, comprising a thiolated thermosensitive polymer crosslinked with an electrophilic polymer;
- wherein the thiolated thermosensitive polymer is prepared by i) conjugating an amphiphilic polymer with a polymer having at least three primary amine groups to provide an intermediate polymer, and ii) thiolating said intermediate polymer to provide the thiolated thermosensitive polymer;
- wherein, prior to crosslinking with the thiolated thermosensitive polymer, the electrophilic polymer has the formula:
- wherein the encircled C represents a core, the encircled polymer represents a hydrophilic polymer, c is an integer selected from 3, 4, 5, 6, 7, 8, 9, or 10, and Q1 is an electrophilic group.
A method of making a hydrogel composition, the method comprising crosslinking an electrophilic polymer with a thiolated thermosensitive polymer;
- wherein the electrophilic polymer has the formula:
- wherein the encircled C represents a core, the encircled polymer represents a hydrophilic polymer, c is an integer selected from 3, 4, 5, 6, 7, 8, 9, or 10, and Q1 is an electrophilic group.
Dependencies are inferred from the claim text.