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US 12,723,078 B2Granted
Monoclonal antibodies against LILRB1 for diagnostic and therapeutic use
AssigneeBoard of Regents, The University of Texas System
InventorsZhiqiang An, Chengcheng Zhang, Ningyan Zhang, Yuanzhi Chen, Heyu Chen
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Abstract
Provided herein are antibodies binding to LILRB1 and the uses of the antibodies in detecting and treating cancer and autoimmune diseases.
Claims36
An isolated monoclonal antibody or an antigen-binding fragment thereof which specifically binds to LILRB1, comprising a heavy chain (HC) variable region (VH) and a light chain (LC) variable region (VL), wherein the VH comprises HC-CDR1 of SEQ ID NO:
- 113, HC-CDR2 of SEQ ID NO:
- 114 and HC-CDR3 of SEQ ID NO:
- 115, and
- wherein the VL comprises LC-CDR1 of SEQ ID NO:
- 434, LC-CDR2 of SEQ ID NO:
- 435 and LC-CDR3 of SEQ ID NO:
- 436.
4 more elements
Dependencies are inferred from the claim text.