Humanized antibodies directed against KCNK9
AssigneesThe Johns Hopkins University, University of Maryland, Baltimore, Kennedy Krieger Institute, Inc.
InventorsJohn J. Laterra, Amy M. Fulton
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Abstract
Provided herein are humanized monoclonal antibodies that bind to potassium two pore domain channel subfamily K member 9 (KCNK9). The humanized monoclonal antibodies comprise (a) a heavy chain variable region comprising an amino acid sequence of SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, or SEQ ID NO: 13; and (b) a light chain variable region comprising an amino acid sequence of SEQ ID NO: 14, SEQ ID NO: 15, or SEQ ID NO: 16. Methods of using the antibodies to inhibit the growth of KCNK9-expressing cells also are provided.
Claims17
A humanized antibody or an antigen-binding fragment thereof that specifically binds to potassium two pore domain channel subfamily K member 9 (KCNK9) and that comprises:
- (a) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 9 and a light chain variable region amino acid sequence of SEQ ID NO:
- 15;
- (b) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 10 and a light chain variable region amino acid sequence of SEQ ID NO:
- 15;
- (c) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 11 and a light chain variable region amino acid sequence of SEQ ID NO:
- 15;
- (d) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 11 and a light chain variable region amino acid sequence of SEQ ID NO:
- 16;
- (e) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 12 and a light chain variable region amino acid sequence of SEQ ID NO:
- 15;
- (f) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 12 and a light chain variable region amino acid sequence of SEQ ID NO:
- 16;
- (g) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 13 and a light chain variable region amino acid sequence of SEQ ID NO:
- 14;
- (h) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 13 and a light chain variable region amino acid sequence of SEQ ID NO:
- 15;
- or
- (i) a heavy chain variable region amino acid sequence of SEQ ID NO:
- 13 and a light chain variable region amino acid sequence of SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.