Loading patent…
AssigneeInstitute of Biotechnology, Xinjiang Academy of Animal Science (China-Australia Sheep Research Centre, Xinjiang Academy of Animal Science)
InventorsZhonghui Li, Wenrong Li, Jinrui Liu, Chenxi Liu, Meiyu Qiu, Yila Ma
Estimating the term…
Disclosed is a sheep PDGFD, nucleic acids encoding PDGFD and recombinant lentivirus, host cell and use thereof, which relate to the technical field of molecular cell biology. The sheep platelet-derived growth factor PDGFD includes one or two of PDGFD-T1 and PDGFD-T2. The amino acid sequence of PDGFD-T1 is set forth in SEQ ID NO:1, and the amino acid sequence of PDGFD-T2 is set forth in SEQ ID NO:2. PDGFD-T1 and PDGFD-T2 are able to significantly inhibit the differentiation and maturation of precursor adipocytes and significantly reduce the mRNA relative expression levels of adipogenic differentiation-related genes CEBPα, PPARγ, FAS, FABP4 and LPL, thereby inhibiting animal fat deposition and improving animal meat quality, and have important guiding significance in the fields of life science, medical science, animal husbandry and the like.
A lentiviral expression vector containing a nucleic acid, wherein the nucleic acid encodes a sheep platelet-derived growth factor D (PDGFD), wherein the PDGFD is PDGFD-T2;
A product for inhibiting animal fat deposition, wherein an active ingredient of the product is one or more selected from the group consisting of a sheep PDGFD, a nucleic acid encoding the sheep PDGFD, a lentivirus expression vector containing the nucleic acid, a recombinant lentivirus containing the lentivirus expression vector, and a host cell containing the nucleic acid;
Dependencies are inferred from the claim text.