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US 12,723,055 B2Granted
Phosphoantigen prodrug compounds
AssigneesUniversity College Cardiff Consultants Limited, The University of Birmingham
InventorsYoucef Mehellou, Benjamin Willcox
Life of this patent
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Abstract
The invention relates to a compound of General Formula (I): wherein R1, R2, R3, R4 and R5 are as defined herein. Compounds and compositions comprising the same exhibit high serum stability and potent activation of the γδ T-cell immune response, so are suitable for use in immunotherapy. The invention also relates to methods of immunotherapy using the compounds of General Formula (I).
Claims10
A compound according to Formula (IV) including all tautomers thereof,
- wherein:
- R3 is a radical according to Formula (V), Formula (VI) or Formula (VII),
- R9 is OH, and
- each of R4 and R5 independently represent H or halo;
- R6 is a C1-4 alkyl chain;
- R7 is a C6-14 aryl group or a benzyl group;
- R8 represents an optionally substituted C5-25 aryl or a 5 to 25 membered heteroaryl group;
- or a salt thereof.
5 more elements
Dependencies are inferred from the claim text.