Tricyclic derivatives and related uses

A compound of Formula (III-a′):

• or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, or tautomer thereof, wherein:
• R1 is C3-C10 cycloalkyl, C6-C10 aryl, 5- to 10-membered heteroaryl, or 3- to 10-membered heterocyclyl, wherein the C3-C10 cycloalkyl, C6-C10 aryl, 5- to 10-membered heteroaryl, or 3- to 10-membered heterocyclyl is optionally substituted with one or more R1a;
• each R1a independently is oxo, halo, cyano, —OH, —NH2, —NO2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NH—C(O)(C1-C6 alkyl), —S(C1-C6 alkyl), —S(O)2(C1-C6 alkyl), —S(O)2(NH2), —C(O)(H), —C(O)NH2, —O(3- to 10-membered heterocyclyl), C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C3-C10 cycloalkyl, C6-C10 aryl, 5- to 10-membered heteroaryl, or 3-to 10-membered heterocyclyl, wherein the —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2 —NH—C(O)(C1-C6 alkyl), —S(C1-C6 alkyl), —S(O)2(C1-C6 alkyl), —O(3- to 10-membered heterocyclyl), C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C3-C10 cycloalkyl, C6-C10 aryl, 5-to 10-membered heteroaryl, or 3- to 10-membered heterocyclyl is optionally substituted with one or more R1b;
• each R1b independently is oxo, halo, cyano, —OH, —O(C1-C6 alkyl), —O(C1-C6 haloalkyl), —O(C2-C6 alkenyl), —O(C2-C6 alkynyl), —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —NH(C1-C6 haloalkyl), —S(C1-C6 alkyl), —S(O)2(C1-C6 alkyl), —C(O)NH2, C1-C6 alkyl, C3-C10 cycloalkyl, or 3-to 10-membered heterocyclyl optionally substituted with oxo;
• R2 is C6-C10 aryl or 5- to 10-membered heteroaryl, wherein the C6-C10 aryl or 5- to 10-membered heteroaryl is optionally substituted with one or more R2a;
• each R2a independently is halo, cyano, —OH, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —SH, —S(O)2NH2, —SF5, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, —S(C1-C6 haloalkyl), —S(C1-C6 alkyl), C3-C10 cycloalkyl, C6-C10 aryl, 5- to 10-membered heteroaryl, or 3- to 10-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, —S(C1-C6 haloalkyl), —S(C1-C6 alkyl), C3-C10 cycloalkyl, C6-C10 aryl, 5- to 10-membered heteroaryl, or 3- to 10-membered heterocyclyl is optionally substituted with one or more R2a1;
• each R2a1 independently is oxo, halo, cyano, —OH, —NH2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, —NH—C(O)(C1-C6 alkyl), —C(O)NH2, or —OC(O)(C1-C6 alkyl), wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, or C1-C6 haloalkyl is optionally substituted with one or more —OH;
• each R3a independently is cyano, halo, —OH, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —N(C1-C6 alkyl)(C1-C6 haloalkyl), —NH—C(O)(C1-C6 alkyl), —O(C3-C10 cycloalkyl), —O(3- to 10-membered heterocyclyl), C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C10 cycloalkyl, 3- to 10-membered heterocyclyl, 5- to 10-membered heteroaryl, —S(O)(═NH)(C1-C6 alkyl), —SO2(C1-C6 alkyl), —S(C1-C6 alkyl), or —S(C1-C6 haloalkyl);
• p is 0, 1, 2, 3, 4, 5, or 6;
• R5 is H, halo, cyano, or C1-C6 alkyl;
• and
• R6 is H, halo, cyano, C1-C6 alkyl, or C1-C6 alkoxy, wherein the C1-C6 alkyl or C1-C6 alkoxy is optionally substituted with one or more —NH2, —NH(C1-C6 alkyl), or —N(C1-C6 alkyl)2, or
• R5 and R6, together with the atoms to which they are attached, form a C4-C10 cycloalkenyl.