Selective neuronal nitric oxide synthase inhibitors
AssigneeNorthwestern University
InventorsRichard B. Silverman, Maris A. Cinelli, Cory T. Reidl
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Abstract
Disclosed are 7-phenyl-2-aminoquinoline compounds that are shown to inhibit the biological activity of neuronal nitric oxide synthases (nNOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of neuronal nitric oxide synthases (nNOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with nNOS activity including neurological diseases and disorders.
Claims20
A compound of a formula:
- or a salt or solvate thereof,
- wherein:
- X is selected from alkyl-amino substituted phenyl, alkyl-amino substituted pyridyl, isoindolinyl, and amino-substituted indanyl;
- and optionally X is substituted or further substituted with a substituent selected from cyano, halo, alkyl, haloalkyl, alkoxy, and substituents having a formula —OCH2—Y, wherein Y is cycloalkyl, aryl, or heteroaryl and wherein Y is optionally substituted with a substituent selected from alkyl, halo, and cyano;
- provided that the compound is not
Dependencies are inferred from the claim text.