US 12,723,028 B2Granted

Heterocyclic compound

AssigneeTakeda Pharmaceutical Company Limited

InventorsYuta Tanaka, Yuta Tanaka, Keiko Kakegawa, Takahito Kasahara, Fumiaki Kikuchi, Takeshi Yamamoto, Tomohiro Ohashi, Zenichi Ikeda, Florian Puenner, Minoru Nakamura, Kazuaki Takami, Masataka Murakami, Masaki Daini, Masaki Seto, Satoshi Mikami, Minoru Sasaki

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Abstract

The present invention provides a compound having a glucosylceramide synthase inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of lysosomal storage diseases (e.g., Gaucher's disease, Fabry's disease, GM1-gangliosidosis, GM2 activator deficiency, Tay-Sachs disease, Sandhoffs disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

Claims12

Dependent claims

A compound represented by the formula (I):

wherein
X1 is C or N,
X2 is C or N,
is a single bond or a double bond,
Ring A is an optionally further substituted 5- or 6-membered aromatic ring,
R1 is a cyano group, a C1-6 alkyl group substituted by 1 to 5 fluorine atoms, an optionally substituted hydroxy group, an optionally substituted amino group, or an optionally substituted cyclic group,
Y1 is CRa wherein Ra is absent, a hydrogen atom or a substituent, or N,
Y2 is CRbRc wherein Rb is a hydrogen atom or a substituent, and Rc is absent, a hydrogen atom or a substituent, or NRd wherein Rd is absent, a hydrogen atom or a substituent,
Y3 is CReRf wherein Re is a hydrogen atom or a substituent, and Rf is absent, a hydrogen atom or a substituent, or NRg wherein Rg is absent, a hydrogen atom or a substituent,
Ring B is a 6-membered ring, and
R2 is
wherein
Z1 is CRh wherein Rh is a hydrogen atom or a substituent, or N,
Z2 is CRi wherein Ri is a hydrogen atom or a substituent, or N,
Z3 is CRj wherein Rj is a hydrogen atom or a substituent, or N,
Z4 is CRk wherein Rk is a hydrogen atom or a substituent, or N,
Z5 is C or N,
Z6 is CRl wherein Rl is a hydrogen atom or a substituent, or N,
Z7 is CRm wherein Rm is a hydrogen atom or a substituent, or N,
Z8 is CRn wherein Rn is a hydrogen atom or a substituent, or N,
Z9 is C or N,
Z10 is C or N,
Z11 is CRo wherein Ro is a hydrogen atom or a substituent, NRp wherein Rp is absent, a hydrogen atom or a substituent, O or S,
Z12 is C or N,
Z13 is CRq wherein Rq is a hydrogen atom or a substituent, NRr wherein Rr is absent, a hydrogen atom or a substituent, O or S,
Z14 is CRs wherein Rs is a hydrogen atom or a substituent, NRt wherein Rt is absent, a hydrogen atom or a substituent, O or S,
Z15 is C or N,
Z16 is CRu wherein Ru is a hydrogen atom or a substituent, NRv wherein Rv is absent, a hydrogen atom or a substituent, O or S,
Z17 is C or N,
Z18 is CRw wherein Rw is a hydrogen atom or a substituent, NRx wherein Rx is absent, a hydrogen atom or a substituent, O or S,
Z19 is C or N,
Ring C1 and Ring C2 are each independently a 6-membered aromatic ring,
Ring C3 is an optionally substituted ring,
R3 is a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted cyclic group, an optionally substituted amino group, SO2R7 or OR8,
R7 is a substituent,
R8 is a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted saturated cyclic group, or an optionally substituted monocyclic unsaturated cyclic group,
Ring D1 and Ring D2 are each independently a 5-membered aromatic ring,
Ring D3 is an optionally substituted ring, and
R4 is a substituent,
or a salt thereof.

37 more elements

A compound or a salt thereof, wherein the compound is selected from the group consisting of:

1-(2-methoxyphenyl)-6-methyl-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
1-(2-methoxyphenyl)-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
1-[2-(morpholin-4-yl)phenyl]-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-2-oxo-N-[4-(trifluoromethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-(6-cyclopropylpyridin-3-yl)-1-(4-fluoro-2-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-N-(6-methoxypyridin-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[4-(difluoromethoxy)phenyl]-1-(4-fluoro-2-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-(6-methoxypyridin-3-yl)-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-(4-chlorophenyl)-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(difluoromethoxy)pyridin-3-yl]-1-(4-fluoro-2-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(morpholin-4-yl)phenyl]-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
2-(4-fluoro-2-methoxyphenyl)-3-oxo-N-(4-phenoxyphenyl)-2,3-dihydropyridazine-4-carboxamide,
1-(4-fluoro-2-methoxyphenyl)-N-[4-(morpholin-4-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(trifluoromethyl)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-(5-cyclopropylpyridin-2-yl)-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-N-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl]-1,2-dihydropyridine-3-carboxamide,
2-(4-fluoro-2-methoxyphenyl)-3-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-2,3-dihydropyridazine-4-carboxamide,
N-(6-cyanopyridin-3-yl)-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(morpholin-4-yl)phenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2-methoxyethoxy)phenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2-methoxyethoxy)phenyl]-N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-3-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-2,3-dihydropyridazine-4-carboxamide,
1-(2-cyano-4-fluorophenyl)-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
N-(5-cyanopyridin-2-yl)-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-(1-cyclopropyl-1H-pyrazol-4-yl)-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-{4-[(morpholin-4-yl)methyl]phenyl}-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[2-(trifluoromethyl)pyrimidin-5-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[5-(trifluoromethyl) pyrazin-2-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[6-(trifluoromethyl)pyridazin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-(1-tert-butyl-1H-pyrazol-3-yl)-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-(4-cyanophenyl)-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[4-(piperidine-1-carbonyl)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-(imidazo[1,2-a]pyridin-6-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[1-(2,2-difluoroethyl)-1H-pyrazol-4-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[1-(difluoromethyl)-1H-pyrazol-4-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(difluoromethyl)pyridin-3-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[4-(cyclopropylmethoxy)phenyl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[2-(difluoromethoxy)pyrimidin-5-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-(2-cyano-4-fluorophenyl)-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[1-(oxan-4-yl)-1H-pyrazol-5-yl]-2-oxo-N-(4-phenoxyphenyl)-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[1-(oxan-4-yl)-1H-pyrazol-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
rac-N-{1-[(2,2-difluorocyclopropyl)methyl]-1H-pyrazol-3-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,3,3,3-pentafluoropropoxy)phenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-[4-(cyanomethyl)phenyl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,3,3,3-pentafluoropropoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[1-(oxan-4-yl)-1H-pyrazol-5-yl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxy-2-methylpropoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxy-2-methylpropyl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[1-(2,2,3,3,3-pentafluoropropyl)-1H-pyrazol-4-yl]-1,2-dihydropyridine-3-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[6-(3,3,3-trifluoropropoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-{1-[(3-fluorooxetan-3-yl)methyl]-1H-pyrazol-4-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-{1-[(1-fluorocyclopropyl)methyl]-1H-pyrazol-4-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2-hydroxy-2-methylpropoxy)phenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-1-[2-methyl-6-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(1-hydroxycyclopropyl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[4-(2-hydroxy-2-methylpropoxy)phenyl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-(2-cyano-4-fluorophenyl)-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1-[1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2-dihydropyridine-3-carboxamide,
2-oxo-N-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
rac-N-{6-[cyclopropyl(hydroxy)methyl]pyridin-3-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
rac-N-{6-[cyclopropyl(hydroxy)methyl]pyridin-3-yl}-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-1-[3-(2,2,2-trifluoroethoxy)pyridazin-4-yl]-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(cyanomethyl)pyridin-3-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-2-oxo-1-[1-(3,3,3-trifluoropropyl)-1H-pyrazol-5-yl]-1,2-dihydropyridine-3-carboxamide,
N-[3-fluoro-4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-[3-fluoro-4-(2-hydroxypropan-2-yl)phenyl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[6-(cyanomethyl)pyridin-3-yl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-cyanopropan-2-yl)pyridin-3-yl]-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-cyanopropan-2-yl)pyridin-3-yl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1-[3-(2,2,2-trifluoroethoxy)pyridazin-4-yl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(2-methoxypropan-2-yl)pyridin-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-methoxypropan-2-yl)pyridin-3-yl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-6-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,6-dihydropyrimidine-5-carboxamide,
1-(4-methoxy-1-methyl-1H-pyrazol-5-yl)-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
2-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
N-[4-(1-hydroxycyclobutyl)phenyl]-2-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(1-hydroxycyclobutyl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxamide,
1-[2-(2,2-difluoropropoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[2-(2,2-difluoroethoxy)-4-fluorophenyl]-2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[2-(2,2-difluoroethoxy)-4-fluorophenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-(2-cyano-4-fluorophenyl)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4-fluoro-2-(2-hydroxy-2-methylpropoxy)phenyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-[4-fluoro-2-(2,2,3,3,3-pentafluoropropoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide,
1-[4,5-difluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,3-dihydropyridazine-4-carboxamide,
2-oxo-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-1-[5-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1,2-dihydropyridine-3-carboxamide,
1-[3,4-difluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
1-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-2-oxo-2′-(2,2,2-trifluoroethoxy)-2H-[1,3′-bipyridine]-3-carboxamide,
(R or S)—N-{6-[cyclopropyl(hydroxy)methyl]pyridin-3-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
(R or S)—N-{6-[cyclopropyl(hydroxy)methyl]pyridin-3-yl}-1-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
2-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-3-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,3-dihydropyridazine-4-carboxamide,
1-[4,5-difluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-oxo-1-[5-(2,2,2-trifluoroethoxy)pyrimidin-4-yl]-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-oxo-2′-(2,2,2-trifluoroethoxy)-2H-[1,3′-bipyridine]-3-carboxamide,
rac-2-oxo-1-[3-(2,2,2-trifluoroethoxy)pyridazin-4-yl]-N-[6-(1,1,1-trifluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1-[3-(2,2,2-trifluoroethoxy)pyridazin-4-yl]-1,2-dihydropyridine-3-carboxamide,
2-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2′-(2,2,2-trifluoroethoxy)-2H-[1,3′-bipyridine]-3-carboxamide,
1-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-1,2-dihydropyridine-3-carboxamide,
1-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-2-oxo-1,2-dihydropyridine-3-carboxamide,
N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[5-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[5-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methyl-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[5-(2-hydroxypropan-2-yl)pyridin-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[6-(2-hydroxypropan-2-yl)pyridin-3-yl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[5-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
rac-N-[4-(1-hydroxyethyl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
rac-2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(1-hydroxyethyl)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
rac-N-[5-(1-hydroxyethyl)pyridin-2-yl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-N-[4-(oxetan-3-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)-3-methylphenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)-2-methylphenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
rac-2-[2-(2,2-difluoroethoxy)phenyl]-3-oxo-N-[4-(oxolan-2-yl)phenyl]-2,3-dihydropyridazine-4-carboxamide,
rac-2-[2-(2,2-difluoroethoxy)phenyl]-3-oxo-N-[4-(oxolan-3-yl)phenyl]-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[2-fluoro-4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[2-fluoro-4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
N-[2-fluoro-4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[2-chloro-4-(2-hydroxypropan-2-yl)phenyl]-2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[2,6-difluoro-4-(2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)-2-methoxyphenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-3-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[2-cyano-4-(2-hydroxypropan-2-yl)phenyl]-2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
3-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[2-fluoro-4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide,
2-[2-(2,2-difluoroethoxy)phenyl]-N-[2-fluoro-4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-methyl-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-methyl-5-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,5-dihydropyridazine-4-carboxamide,
N-[2-chloro-4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2-[2-(2,2-difluoroethoxy)phenyl]-3-oxo-2,3-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(difluoromethyl)-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
3-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(difluoromethyl)-5-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxy-2-methylpropoxy)phenyl]-2-methyl-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(difluoromethyl)-N-[4-(2-hydroxy-2-methylpropoxy)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
N-[4-(2-hydroxypropan-2-yl)phenyl]-2-methyl-5-oxo-6-[2-(2,2,2-trifluoroethoxy)phenyl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-(2,4-difluorophenyl)-2-(2-hydroxy-2-methylpropyl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(2-hydroxy-2-methylpropyl)-5-oxo-N-[4-(2,2,2-trifluoroethoxy)phenyl]-2,5-dihydropyridazine-4-carboxamide,
2-cyclopropyl-6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
ethyl 5-({2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carbonyl}amino)thiophene-2-carboxylate,
6-[2-(2,2-difluoroethoxy)phenyl]-N-(4-fluorophenyl)-2-(2-hydroxy-2-methylpropyl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
N-[4-(2-cyanopropan-2-yl)phenyl]-6-[2-(2,2-difluoroethoxy)phenyl]-2-methyl-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(difluoromethoxy)phenyl]-2-(2-hydroxy-2-methylpropyl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(2-hydroxy-2-methylpropyl)-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-[(oxetan-3-yl)methyl]-5-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-methyl-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(difluoromethyl)-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(2-hydroxy-2-methylpropyl)-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(2,2-difluoroethyl)-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-[(oxetan-3-yl)methyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-(2,4-difluorophenyl)-2-[(oxetan-3-yl)methyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-(2,4-difluorophenyl)-2-(oxetan-3-yl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-2-(oxetan-3-yl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(oxetan-3-yl)-5-oxo-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(difluoromethyl)phenyl]-2-methyl-5-oxo-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(2,2-difluoroethyl)-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-(oxetan-3-yl)-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
6-[2-(2,2-difluoroethoxy)phenyl]-2-[(oxetan-3-yl)methyl]-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
2-cyclopropyl-6-[2-(2,2-difluoroethoxy)phenyl]-5-oxo-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
N-[4-(2-cyanopropan-2-yl)phenyl]-2-methyl-5-oxo-6-[2-(2,2,2-trifluoroethoxy)phenyl]-2,5-dihydropyridazine-4-carboxamide,
N-[4-(2-cyanopropan-2-yl)phenyl]-6-[2-(2,2-difluoroethoxy)phenyl]-2-(oxetan-3-yl)-5-oxo-2,5-dihydropyridazine-4-carboxamide,
N-[4-(2-cyanopropan-2-yl)phenyl]-2-cyclopropyl-6-[2-(2,2-difluoroethoxy)phenyl]-5-oxo-2,5-dihydropyridazine-4-carboxamide,
rac-6-[2-(2,2-difluoroethoxy)phenyl]-N-[4-(2-hydroxypropan-2-yl)phenyl]-5-oxo-2-(oxolan-3-yl)-2,5-dihydropyridazine-4-carboxamide,
ethyl 4-({2-[2-(2,2-difluoroethoxy)phenyl]-6-methyl-3-oxo-2,3-dihydropyridazine-4-carbonyl}amino)benzoate,
rac-6-[2-(2,2-difluoroethoxy)phenyl]-5-oxo-2-(oxolan-3-yl)-N-[6-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)pyridin-3-yl]-2,5-dihydropyridazine-4-carboxamide,
rac-6-[2-(2,2-difluoroethoxy)phenyl]-5-oxo-2-(oxolan-3-yl)-N-[4-(1,1,3,3-tetrafluoro-2-hydroxypropan-2-yl)phenyl]-2,5-dihydropyridazine-4-carboxamide,
6-acetyl-N-[4-(difluoromethoxy)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
ethyl 5-{[4-(difluoromethoxy)phenyl]carbamoyl}-6-oxo-1-[2-(2,2,2-trifluoroethoxy)phenyl]-1,6-dihydropyridazine-3-carboxylate,
rac-N-[4-(difluoromethoxy)phenyl]-6-(1-hydroxyethyl)-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[4-(difluoromethoxy)phenyl]-6-(2-hydroxypropan-2-yl)-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
N-[4-(2-cyanopropan-2-yl)phenyl]-6-(2-hydroxypropan-2-yl)-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide,
6-(2-hydroxypropan-2-yl)-N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide, and
6-(2-hydroxypropan-2-yl)-3-oxo-N-[4-(prop-1-en-2-yl)phenyl]-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide.

200 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/630,442Filed 28 Jul 2020
Priority: JP 2019-13917429 Jul 2019
Published: US 2022/0289679 A115 Sep 2022
Granted: 1 Sep 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 213/82
Amides; Imides: in position 3
C07D 237/14
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…