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US 12,723,020 B2Granted
Process for preparing solriamfetol hydrochloride
AssigneeProcos S.P.A.
InventorsDavide Gornati, Fabio Morana, Jacopo Roletto, Paolo Paissoni
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Abstract
The present invention concerns a novel process for preparing solriamfetol hydrochloride.
Claims8
A process for preparing (2R)-2-amino-3-phenylpropylcarbamate hydrochloride of formula (I)
- comprising the steps of:
- a. adding (R)-mandelic acid and at least one aldehyde to a suspension of L-phenylalanine in acetic acid, thus obtaining a D-phenylalanine:
- (R)-mandelic acid complex, wherein the D-phenylalanine:
- (R)-mandelic acid molar ratio is 1:1;
- b. isolating the D-phenylalanine of formula (II)
- from the D-phenylalanine:
- (R)-mandelic acid complex obtained from step a;
- c. reacting the D-phenylalanine obtained from step b. with a reducing agent, thus obtaining (R)-(+)-2-amino-3-phenyl-1-propanol of formula (III)
- d. reacting (R)-(+)-2-amino-3-phenyl-1-propanol obtained from step c. with an acid thus obtaining (2R)-2-amino-3-phenylpropilcarbamate of formula (IV)
- e. converting (2R)-2-amino-3-phenylpropilcarbamate obtained from step d. into said (2R)-2-amino-3-phenylpropylcarbamate hydrochloride of formula (I).
7 more elements
A process for preparing a D-phenylalanine:
- (R)-mandelic acid complex, wherein the D-phenylalanine:
- (R)-mandelic acid molar ratio is 1:1, comprising adding (R)-mandelic acid and at least one aldehyde to a suspension of L-phenylalanine in acetic acid.
A process for preparing D-phenylalanine of formula (II)
- comprising the steps of:
- i. adding (R)-mandelic acid and at least one aldehyde to a suspension of L-phenylalanine in acetic acid, thus obtaining a D-phenylalanine:
- (R)-mandelic acid complex, wherein the D-phenylalanine:
- (R)-mandelic acid molar ratio is 1:1;
- and
- ii. isolating D-phenylalanine from D-phenylalanine:
- (R)-mandelic acid complex obtained from step i.
4 more elements
Dependencies are inferred from the claim text.