# US 12,721,984 B2 · Apparatus for producing micro-arrays, and method for producing a micro-array

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- Number: US 12,721,984 B2
- Document ID: US12721984B2
- Status: Granted
- Kind: B2
- Application number: 17/917,318
- Filed: 2021-03-25
- Published: 2023-05-18
- Granted: 2026-09-01
- Earliest claimed: 2020-04-09
- Assignees: LTS Lohmann Therapie-Systeme AG
- Applicants: LTS Lohmann Therapie-Systeme AG
- Inventors: Stefan Henke; Jörg Bender; Hagen Trommer; Sebastian Scherr
- Web page: https://patentgrep.com/patent/US12721984B2

## CPC

- A61M 37/0015: {by using microneedles}
- A61M 2037/0046: {Solid microneedles}
- A61M 2037/0053: {Methods for producing microneedles}
- B29L 2031/756: {Microarticles, nanoarticles}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- B29L: INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES

## Abstract

An apparatus for producing microarrays includes a die. A plurality of cavities is formed in the die. A cover element is additionally provided in order to cover regions between the cavities. In this manner it is possible to remove an active agent-containing liquid from the regions formed between the cavities when metering said liquid. This is achieved in that the cover element is removed again. An active agent-free liquid can then be metered, with which a remaining portion of the cavities are filled, and a support layer is formed on the upper surface of the die.

## Claims

### Claim 1

A method for producing a microarray by means of an apparatus, the apparatus comprising:
a die comprising a plurality of microneedle cavities; and
a cover element,
wherein the cover element covers regions between the plurality of microneedle cavities during metering of an active agent-containing material into the plurality of microneedle cavities,
wherein the cover element is removable after metering of the active agent-containing material such that there is no active agent-containing material in the regions covered by the cover element, and
wherein the method comprises the steps of:
arranging the cover element on a die, such that regions between the plurality of microneedle cavities of the die are covered;
metering active agent-containing liquid into the plurality of microneedle cavities;
removing the cover element; and
metering an active agent-free liquid into the plurality of microneedle cavities and onto an upper surface of the die for creating a support layer of the microarray.

### Claim 2 (depends on 1)

The method for producing a microarray according to claim 1, in which a drying step is carried out prior to removing the cover element.