Adaptive method and system for a personalized daily infusion therapy of Parkinson's disease

A system for managing an infusion therapy for the treatment of Parkinson's disease, said management occurring through a determination of a motor status of patients affected by said Parkinson's disease, wherein said motor status can be in one of the following phases:

• OFF phase, where Parkinson's symptoms of rigidity, tremor and bradykinesia, emerge;
• ON phase where said Parkinson's symptoms markedly improve;
• DYS phase where involuntary movements, called dyskinesias, emerge;
• wherein said analysis uses as detectors of said symptoms the following parameters:
• voice analysis;
• face analysis;
• tremor analysis;
• movement analysis;
• and levodopa and metabolite levels of monoamines in the sub-cutaneous interstitial liquid of said patients;
• said system comprising:
• an electronic bracelet, equipped with an accelerometer, a magnetometer and a gyroscope, three-axial, for collecting data continuously about tremor and movement;
• a photo-camera to shoot face expressions, to be actuated upon request of a patient;
• a recorder to record the patient voice, to be actuated upon request of the patient;
• a micro-dialysis pump connected to an analysing unit and to a sub-cutaneous needle, adapted to collect and analyse samples of interstitial liquid to determine the levodopa and metabolite levels of the monoamines in said sub-cutaneous interstitial liquid;
• a processing device, equipped with a suitable software which, using a movement stabilizing algorithm, adapted to integrate data about movement, tremor, face, voice and levodopa and metabolite levels of monoamines in said sub-cutaneous interstitial liquid, computes an infusion rate of a drug necessary to keep an ON motor status, using as feedback data about a starting therapeutic scheme;
• an electronic interface, connected to said processing device, adapted to modify the infusion rate of the drug with a new rate computed by said movement stabilizing algorithm.